Abstract |
Termination of early pregnancy (less than 49 days of amenorrhea) was induced in 75 patients with the combination of the antigestagen mifepristone and a prostaglandin analogue, meteneprost. After 48 h a single oral dose of 600 mg of mifepristone was followed by a 10 mg meteneprost vaginal pessary. Pregnancy was confirmed by clinical and ultrasound examinations and plasma HCG assessment. Complete abortion occurred in 72 patients (96%) and the three others required a surgical uterine aspiration. Bleeding continued for 4 to 12 days (mean = 8). Uterine pain and side effects occurred during the 3 h following the use of prostaglandin. Only minor analgesic were required in 30 patients. The combination of mifepristone and meteneprost is a safe and effective method to terminate an early pregnancy.
|
Authors | B Maria, F Stampf, A Goepp, C Dubois |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 37
Issue 1
Pg. 35-40
(Oct 1990)
ISSN: 0301-2115 [Print] Ireland |
PMID | 2376278
(Publication Type: Journal Article)
|
Chemical References |
- Abortifacient Agents
- Abortifacient Agents, Nonsteroidal
- Prostaglandins E, Synthetic
- meteneprost
- Mifepristone
- 16,16-Dimethylprostaglandin E2
|
Topics |
- 16,16-Dimethylprostaglandin E2
(administration & dosage, adverse effects, analogs & derivatives)
- Abortifacient Agents
(administration & dosage)
- Abortifacient Agents, Nonsteroidal
(administration & dosage, adverse effects)
- Abortion, Induced
(methods)
- Abortion, Legal
- Administration, Intravaginal
- Administration, Oral
- Adolescent
- Adult
- Female
- France
- Humans
- Mifepristone
(administration & dosage, adverse effects)
- Pregnancy
- Pregnancy Trimester, First
- Prostaglandins E, Synthetic
(administration & dosage)
|