Abstract | STUDY OBJECTIVE: METHODS: This was a retrospective study conducted at a Level 1 trauma center from April 2009 to July 2010. Patients older than 55 years with isolated mild head injury (Glasgow Coma Scale score 13-15 and Abbreviated Injury Score < 3 in nonhead body region) were included. Demographic, clinical, and outcome data were abstracted from an existing traumatic brain injury database. The primary end point of unfavorable extended Glasgow Outcome Score at 6 months was compared between patients with and without preinjury warfarin or clopidogrel use. RESULTS: Seventy-seven eligible patients were identified: 27 (35%) with preinjury warfarin or clopidogrel use and 50 (65%) without. Baseline characteristics (sex, Glasgow Coma Scale score, Injury Severity Score, computed tomography score, and in-hospital mortality) were similar between cohorts, although the preinjury warfarin or clopidogrel cohort was older than the control group (P < .05). Patients in the preinjury warfarin or clopidogrel cohort were more likely to have an unfavorable outcome (16/27; 59.3%; 95% confidence interval, 40.7%-77.8%) as compared with those without (18/50; 36.0%; 95% confidence interval, 22.7%-49.3%) (P = .05). CONCLUSION:
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Authors | Daniel K Nishijima, Kiarash Shahlaie, Korak Sarkar, Nancy Rudisill, James F Holmes |
Journal | The American journal of emergency medicine
(Am J Emerg Med)
Vol. 31
Issue 8
Pg. 1244-7
(Aug 2013)
ISSN: 1532-8171 [Electronic] United States |
PMID | 23759685
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Anticoagulants
- Platelet Aggregation Inhibitors
- Warfarin
- Clopidogrel
- Ticlopidine
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Topics |
- Aged
- Aged, 80 and over
- Anticoagulants
(adverse effects)
- Clopidogrel
- Female
- Glasgow Coma Scale
- Humans
- Injury Severity Score
- Intracranial Hemorrhage, Traumatic
(complications, diagnosis)
- Male
- Middle Aged
- Platelet Aggregation Inhibitors
(adverse effects)
- Prognosis
- Retrospective Studies
- Risk Factors
- Ticlopidine
(adverse effects, analogs & derivatives)
- Trauma Centers
(statistics & numerical data)
- Warfarin
(adverse effects)
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