Klotho gene polymorphism of rs3752472 is associated with the risk of urinary calculi in the population of Han nationality in Eastern China.

Abstract

BACKGROUND/AIMS:

The incidence of urolithiasis has considerably increased throughout the world in the last two decades. Clinical researches have showed an association between oxidative stress and stone formation. Emerging evidence indicated a novel function for klotho protein in anti-oxidative stress. In this study, we aimed at investigating a possible relationship between klotho gene polymorphisms and the risk of calcium oxalate urolithiasis in the population of Han nationality in Eastern China.

METHODS:

Klotho gene polymorphisms rs3752472 in exon3, rs650439 in intron 4 and rs577912 in intron 1 were investigated in 426 patients with calcium oxalate stones compared with 282 age-matched healthy volunteers with no history of stone formation, using TaqMan SNP Genotyping Assays.

RESULTS:

Significant differences were found between rs3752472 and the risk of nephrolithiasis as CC genotype of rs3752472 klotho polymorphism had almost 2-fold increased stone risk compared with the heterozygote genotype CT and homozygous genotype TT(95% CI=1.013-2.255, OR=1.512,p=0.043).

CONCLUSION:

Our results showed that the rs3752472 polymorphism of klotho gene is associated with the risk of calcium oxalate urolithiasis and may act as a risk factor during stone formation in our study population.

• Authors: Chen Xu, Ri-jin Song, Jie Yang, Bin Jiang, Xiao-lan Wang, Wei Wu, Wei Zhang
• Journal: Gene (Gene) Vol. 526 Issue 2 Pg. 494-7 (Sep 10 2013) ISSN: 1879-0038 [Electronic] Netherlands
• PMID: 23756195 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Glucuronidase
• Klotho Proteins

Topics

• Adolescent
• Adult
• Aged
• Alleles
• Asian People (genetics)
• Case-Control Studies
• China
• Female
• Gene Frequency
• Genotype
• Glucuronidase (genetics)
• Humans
• Klotho Proteins
• Male
• Middle Aged
• Polymorphism, Genetic
• Risk
• Urinary Calculi (diagnosis, genetics)
• Young Adult