TCTP overexpression is associated with the development and progression of glioma.

Abstract

Upregulation of translationally controlled tumor protein (TCTP) has been reported in a variety of malignant tumors. However, the impact of TCTP in glioma remains unclear. The objective of this study was to investigate the expression and prognostic value of TCTP in glioma patients. Western blot analysis was used to characterize the expression patterns of TCTP in 45 glioma and 22 normal brain tissues. Immunohistochemistry on a tissue microarray containing 127 cases of glioma was performed to analyze the association between TCTP expression and clinicopathological features. Compared with normal brain tissues, TCTP expression was significantly higher in glioma tissues (p <0.001). In addition, high TCTP expression in glioma was significantly associated with advanced pathological grade (p = 0.018). Kaplan-Meier analysis showed that patients with glioma and higher TCTP expression tend to have shorter overall survival time (p <0.001). In multivariate analysis, TCTP expression was proved to be an independent prognostic factor for patients with glioma (p <0.001). In conclusion, this study confirmed the overexpression of TCTP and its association with tumor progression in glioma. It also provided the first evidence that TCTP expression in glioma was an independent prognostic factor of patients, which might be a potential diagnostic and therapeutic target of glioma.

• Authors: Xia Miao, Yong-Bin Chen, Sheng-Long Xu, Tao Zhao, Jun-Ye Liu, Yu-Rong Li, Jin Wang, Jie Zhang, Guo-Zhen Guo
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 34 Issue 6 Pg. 3357-61 (Dec 2013) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 23749504 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• TPT1 protein, human
• Tumor Protein, Translationally-Controlled 1

Topics

• Adult
• Biomarkers, Tumor (metabolism)
• Blotting, Western
• Brain Neoplasms (metabolism, pathology, surgery)
• Disease Progression
• Female
• Glioma (metabolism, pathology, surgery)
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Multivariate Analysis
• Neoplasm Grading
• Prognosis
• Tissue Array Analysis
• Treatment Outcome
• Tumor Protein, Translationally-Controlled 1