HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Epoxiconazole-induced degeneration in rat placenta and the effects of estradiol supplementation.

Abstract
Epoxiconazole (CAS-No. 133855-98-8) was recently shown to cause both a marked depletion of maternal estradiol blood levels and a significantly increased incidence of late fetal mortality when administered to pregnant rats throughout gestation (GD 7-18 or 21); estradiol supplementation prevented this epoxiconazole effect in rats (Stinchcombe et al., 2013), indicating that epoxiconazole-mediated estradiol depletion is a critical key event for induction of late fetal resorptions in rats. For further elucidation of the mode of action, the placentas from these modified prenatal developmental toxicity experiments with 23 and 50 mg/kg bw/d epoxiconazole were subjected to a detailed histopathological examination. This revealed dose-dependent placental degeneration characterized by cystic dilation of maternal sinuses in the labyrinth, leading to rupture of the interhemal membrane. Concomitant degeneration occurred in the trophospongium. Both placentas supporting live fetuses and late fetal resorptions were affected; the highest degree of severity was observed in placentas with late resorptions. Placental degeneration correlated with a severe decline in maternal serum estradiol concentration. Supplementation with 0.5 and 1.0 μg of the synthetic estrogen estradiol cyclopentylpropionate per day reduced the severity of the degeneration in placentas with live fetuses. The present study demonstrates that both the placental degeneration and the increased incidence of late fetal resorptions are due to decreased levels of estrogen, since estrogen supplementation ameliorates the former and abolishes the latter.
AuthorsMaria Cecilia Rey Moreno, Karma C Fussell, Sibylle Gröters, Steffen Schneider, Volker Strauss, Stefan Stinchcombe, Ivana Fegert, Mariana Veras, Bennard van Ravenzwaay
JournalBirth defects research. Part B, Developmental and reproductive toxicology (Birth Defects Res B Dev Reprod Toxicol) Vol. 98 Issue 3 Pg. 208-21 (Jun 2013) ISSN: 1542-9741 [Electronic] United States
PMID23749492 (Publication Type: Journal Article)
Copyright© 2013 Wiley Periodicals, Inc.
Chemical References
  • Epoxy Compounds
  • Estrogens
  • Triazoles
  • Estradiol
  • epoxiconazole
Topics
  • Animals
  • Dietary Supplements
  • Embryo Implantation (drug effects)
  • Epoxy Compounds (toxicity)
  • Estradiol (blood, pharmacology)
  • Estrogens (metabolism)
  • Female
  • Fetus (drug effects, pathology)
  • Gestational Age
  • Placenta (drug effects, pathology)
  • Pregnancy
  • Rats
  • Rats, Wistar
  • Triazoles (toxicity)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: