Abstract | OBJECTIVE: The Observational Study on Cognitive function And systolic blood pressure Reduction (OSCAR) was designed to evaluate the impact of eprosartan-based therapy on cognitive function in a cohort of 25,745 hypertensive subjects followed for six months. METHODS: In this supplementary analysis, we studied the relationship between eprosartan-based therapy and cognitive function (assessed using the Mini-Mental State Examination (MMSE)) after 12-month follow-up of 3600 patients (the long-term follow-up on-treatment population). RESULTS: Reduction in blood pressure was sustained over 12 months, with mean systolic blood pressure/diastolic blood pressure 130.9/79 mmHg at one year, compared with 164.3/92.8 mmHg at baseline (p<0.001). The overall mean MMSE score at completion of 12-month follow-up was significantly increased from baseline (27.8 ± 2.7 vs. 26.3 ± 3.5; p<0.001). The increase in MMSE score was observed when the population was stratified by age (p<0.001) and in a subgroup of patients with cerebrovascular disease at baseline (n=290) (p<0.001, 12 months vs. baseline). CONCLUSIONS: In this cohort of patients, use of eprosartan-based treatment for one year was associated with sustained reduction in blood pressure and stabilization or improvement of MMSE scores. These data are supportive of a role for blood pressure control in the prevention or delay of cognitive decline.
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Authors | Olivier Hanon, Yong-Seok Lee, Atul Pathak, OSCAR Publication Group |
Journal | Journal of the renin-angiotensin-aldosterone system : JRAAS
(J Renin Angiotensin Aldosterone Syst)
Vol. 16
Issue 2
Pg. 366-73
(Jun 2015)
ISSN: 1752-8976 [Electronic] England |
PMID | 23748626
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2013. |
Chemical References |
- Acrylates
- Imidazoles
- Thiophenes
- eprosartan
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Topics |
- Acrylates
(pharmacology, therapeutic use)
- Aged
- Aged, 80 and over
- Blood Pressure
(drug effects)
- Cognition
(drug effects)
- Demography
- Diastole
(drug effects)
- Female
- Follow-Up Studies
- Humans
- Hypertension
(drug therapy, physiopathology)
- Imidazoles
(pharmacology, therapeutic use)
- Male
- Middle Aged
- Neuropsychological Tests
- Systole
(drug effects)
- Thiophenes
(pharmacology, therapeutic use)
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