Abstract |
Baculoviruses are highly specific and only capable of replication in arthropod hosts. The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is the most studied baculovirus at the molecular level and the Anticarsia gemnatalis multiple nucleopolyhedrovirus (AgMNPV) is the most used viral insecticide worldwide. AcMNPV have also been shown to stimulate the mammalian immune response acting as an adjuvant. In order to evaluate the effects of AgMNPV in modulating macrophage and lymphocyte activation, we have stimulated these cells in vitro and inoculated BALB/c mice intranasally with the two viral phenotypes ( PIBs and BVs) and compared with the response induced by the same phenotypes of AcMNPV. Our results showed that baculoviruses are able to modulate mammalian immune response; in vitro they increase phagocytosis, NO2 production and Th1 cells response. In vivo, AgMNPV BVs or PIBs do not induce an inflammatory reaction in normal lung but during a fungal lung infection they can change the type of adaptive response developed. Considering our data, AgMNPV can be considered more useful as a vaccine vector or immune adjuvant than AcMNPV.
|
Authors | Anamelia Lorenzetti Bocca, Maria Creuza do Espirito Santos Barros, Grace Kelly Menezes Martins, Ana Carolina Oliveira de Araújo, Marcio Jerônimo Souza, Alice Melo Ribeiro, Florêncio Figueiredo, Bergmann Morais Ribeiro |
Journal | Virus research
(Virus Res)
Vol. 176
Issue 1-2
Pg. 119-27
(Sep 2013)
ISSN: 1872-7492 [Electronic] Netherlands |
PMID | 23747526
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2013 Elsevier B.V. All rights reserved. |
Chemical References |
|
Topics |
- Animals
- Cytokines
(metabolism)
- Lymphocyte Activation
- Lymphocytes
(immunology, virology)
- Macrophage Activation
- Macrophages
(immunology, virology)
- Mice
- Mice, Inbred BALB C
- Nitric Oxide
(metabolism)
- Nucleopolyhedroviruses
(immunology)
- Phagocytosis
|