Abstract | INTRODUCTION: AREAS COVERED: A literature review summarizing the most recent data in terms of ephrins and their ligands and their association with different types of pain. Moreover, the latest knowledge regarding the involvement of ephrins/ Eph receptors in pain modulation as well as its possible therapeutic perspectives are presented. EXPERT OPINION: The ephrins/ Eph receptors system seems to be an emerging target for pain drug discovery, because it is involved in the pathophysiology of many types of pain. The modulation of different types of pain by selective agonists or antagonists may hold tremendous therapeutic potential in various pain conditions mentioned in this review. However, the current limited but promising data, merit consideration and further investigation.
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Authors | Ioanna Vasileiou, Ioannis Adamakis, Efstratios Patsouris, Stamatios Theocharis |
Journal | Expert opinion on therapeutic targets
(Expert Opin Ther Targets)
Vol. 17
Issue 8
Pg. 879-87
(Aug 2013)
ISSN: 1744-7631 [Electronic] England |
PMID | 23746169
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Animals
- Ephrins
(metabolism)
- Humans
- Pain
(metabolism)
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