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Does a monovalent inactivated human rotavirus vaccine induce heterotypic immunity? Evidence from animal studies.

Abstract
There is substantial evidence for broad cross-reactive immunity and heterotypic protection among human rotavirus strains in children with natural infection or with monovalent Rotarix vaccination. In this commentary, we addressed this same topic by testing sera of guinea pigs and gnotobiotic piglets that were intramuscularly immunized with an inactivated human rotavirus vaccine and also demonstrated a broad cross-protective immunity among human rotavirus strains. Our findings from a single human strain in animal studies bode well for a low cost and efficacious inactivated vaccine to protect children against rotavirus disease throughout the world.
AuthorsBaoming Jiang, Yuhuan Wang, Roger I Glass
JournalHuman vaccines & immunotherapeutics (Hum Vaccin Immunother) Vol. 9 Issue 8 Pg. 1634-7 (Aug 2013) ISSN: 2164-554X [Electronic] United States
PMID23744507 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • RIX4414 vaccine
  • Rotavirus Vaccines
  • Vaccines, Attenuated
  • Vaccines, Inactivated
Topics
  • Animals
  • Antibodies, Neutralizing (blood, immunology)
  • Antibodies, Viral (blood, immunology)
  • Child
  • Child, Preschool
  • Cross Protection
  • Cross Reactions
  • Guinea Pigs
  • Humans
  • Injections, Intramuscular
  • Rotavirus Infections (prevention & control)
  • Rotavirus Vaccines (administration & dosage, immunology)
  • Swine
  • Vaccines, Attenuated (administration & dosage, immunology)
  • Vaccines, Inactivated (administration & dosage, immunology)

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