Emmprin and KSHV: new partners in viral cancer pathogenesis.

Abstract

Emmprin (CD147; basigin) is a multifunctional glycoprotein expressed at higher levels by cancer cells and stromal cells in the tumor microenvironment. Through direct effects within tumor cells and promotion of tumor-stroma interactions, emmprin participates in induction of tumor cell invasiveness, angiogenesis, metastasis and chemoresistance. Although its contribution to cancer progression has been widely studied, the role of emmprin in viral oncogenesis still remains largely unclear, and only a small body of available literature implicates emmprin-associated mechanisms in viral pathogenesis and tumorigenesis. We summarize these data in this review, focusing on the role of emmprin in pathogenesis associated with the Kaposi sarcoma-associated herpesvirus (KSHV), a common etiology for cancers arising in the setting of immune suppression. We also discuss future directions for mechanistic studies exploring roles for emmprin in viral cancer pathogenesis.

• Authors: Lu Dai, Lihua Bai, Ying Lu, Zengguang Xu, Krys Reiss, Luis Del Valle, Johnan Kaleeba, Bryan P Toole, Chris Parsons, Zhiqiang Qin
• Journal: Cancer letters (Cancer Lett) Vol. 337 Issue 2 Pg. 161-6 (Sep 01 2013) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 23743354 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Basigin

Topics

• Animals
• Basigin (metabolism)
• Cell Movement
• Cell Transformation, Viral
• Disease Progression
• Drug Resistance, Neoplasm
• Herpesvirus 8, Human (pathogenicity)
• Humans
• Immunocompromised Host
• Neoplasm Invasiveness
• Sarcoma, Kaposi (drug therapy, metabolism, pathology, virology)
• Signal Transduction