A multicentric, open label, randomised, postmarketing efficacy study comparing multidose of lincomycin hydrochloride capsule 500 mg with multidose cefpodoxime proxetil tablet 200 mg in patients with tonsillitis, sinusitis.

Abstract

Tonsillitis causes considerable short and medium term morbidity, and can be recurrent. Sinusitis can be acute (less than 4 weeks), subacute (4-8 weeks) or chronic (8 weeks or more). To study the comparative efficacy and safety of multidose treatments of lincomycin hydrochloride 500 mg capsules against cefpodoxime proxetil 200 mg tablets on its outcome in the Indian scenario are the aims and objective of the study. A total of 41 tonsillitis, sinusitis cases of either gender aged above 18 years were enrolled in the study. The diagnosis of sonsillitis, sinusitis was made based on examination of symptoms and throat swab. A randomised treatment of either lincomycin hydrochloride 500 mg capsules or cefpodoxime proxetil 200 mg tablets twice daily for five days alongwith other concomitant medications depending on related symptoms was given to 40 patients. At the end of study, all patients were re-evaluated and the response rate was assessed. The most common clinical symptoms were body temperature, headache, throat pain, postnasal discharge, mucopus, odynophagia, sinus tenderness, nasal congestion, pharyngeal congestion and tonsillar congestion. The overall response rate of lincomycin hydrochloride in all the symptoms except headache was more effective than cefpodoxime proxetil. Out of 100% (n = 20) patients in each group, 67.89% in lincomycin and 52.27% in cefpodoxime patients achieved complete relief, in all the clinical symptoms. The study suggests that lincomycin hydrochloride capsules, a conventional antibiotic indicates effective treatment for relief from tonsillitis and sinusitis, as compared to new third generation antibiotic.

• Authors: Ajay Kothadiya
• Journal: Journal of the Indian Medical Association (J Indian Med Assoc) Vol. 110 Issue 8 Pg. 580-3 (Aug 2012) ISSN: 0019-5847 [Print] India
• PMID: 23741829 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• cefpodoxime proxetil
• Lincomycin
• Ceftizoxime

Topics

• Adult
• Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use)
• Ceftizoxime (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Female
• Humans
• Lincomycin (administration & dosage, adverse effects, therapeutic use)
• Male
• Middle Aged
• Product Surveillance, Postmarketing
• Scarlet Fever (drug therapy, prevention & control)
• Sinusitis (drug therapy, microbiology)
• Streptococcal Infections (drug therapy)
• Streptococcus pyogenes
• Tonsillitis (drug therapy, microbiology)