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Influence of novel supramolecular substance, [2] rotaxane, on the caspase signaling pathway in melanoma and colon cancer cells in vitro.

Abstract
We studied the influence of novel supramolecular substance, [2] rotaxane (TRO-A0001), on caspase signaling and cell viability in cancer cell lines. TRO-A0001 suppressed concentration-dependently cell proliferation. Expression of the cleaved-form caspase-3 and PARP was significantly increased in cells exposed to TRO-A0001. The expression of Bax was increased by TRO-A0001. Furthermore, the down-regulation of Bax by siRNA resulted in growth activation significantly. The morphological analysis demonstrated that TRO-A0001 increased the levels of apoptotic cells in human cancer cell lines. These results suggest that TRO-A0001 induces apoptosis in cancer cells and holds potential as a new anti-tumor medicine.
AuthorsKazuki Hara, Tatsuya Beppu, Masahiko Kimura, Yoshihiko Fujita, Toshikazu Takata, Kazuto Nishio, Nobufumi Ono
JournalJournal of pharmacological sciences (J Pharmacol Sci) Vol. 122 Issue 2 Pg. 153-7 ( 2013) ISSN: 1347-8648 [Electronic] Japan
PMID23739594 (Publication Type: Journal Article)
Chemical References
  • BAX protein, human
  • Macromolecular Substances
  • Rotaxanes
  • bcl-2-Associated X Protein
  • Caspases
Topics
  • Adenocarcinoma (pathology)
  • Apoptosis (drug effects, genetics)
  • Caspases (metabolism, physiology)
  • Colonic Neoplasms (pathology)
  • Humans
  • Macromolecular Substances
  • Melanoma (pathology)
  • Molecular Targeted Therapy
  • Rotaxanes (pharmacology)
  • Signal Transduction (drug effects, genetics, physiology)
  • Tumor Cells, Cultured
  • bcl-2-Associated X Protein (metabolism)

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