[Developmental dysphasia in children: perspectives of neurotrophic therapy].

Developmental dysphasia (alalia) represents a severe speech and language disorder in children. To assess the efficacy of treatment with cerebrolysin, we have examined 60 children with developmental dysphasia, aged from 3 to 4 years. Group 1 (30 patients) received cerebrolysin (monotherapy, daily dosage 0.1 ml/kg, in the morning hours, on each other day, i.m., 30 injections in total) during 2 months. Group 2 (controls, 30 patients) did not receive pharmacotherapy. A significant improvement of expressive, impressive speech and speech attention was observed in group 1 after the treatment. The active vocabulary increased by a factor of 3.5 and phrases number in colloquial speech by a factor of 5, versus 1.5 in the control group. According to parents' questionnaires, the treatment resulted in the decrease of psychasthenic, psychosomatic problems, motor clumsiness and hyperactivity along with the improvement of attention, emotional control and behavioral measures. The positive effect of cerebrolysin on the motor development was demonstrated by the assessment of motor milestones.
AuthorsN N Zavadenko, E V Kozlova
JournalZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoĭ promyshlennosti Rossiĭskoĭ Federatsii, Vserossiĭskoe obshchestvo nevrologov [i] Vserossiĭskoe obshchestvo psikhiatrov (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 113 Issue 5 Pt 2 Pg. 43-7 ( 2013) ISSN: 1997-7298 [Print] Russia (Federation)
PMID23739513 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Amino Acids
  • Nootropic Agents
  • cerebrolysin
  • Amino Acids (administration & dosage, therapeutic use)
  • Brain (drug effects, physiopathology)
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Humans
  • Language Development Disorders (drug therapy, physiopathology, psychology)
  • Male
  • Motor Activity
  • Nootropic Agents (administration & dosage, therapeutic use)
  • Speech (drug effects, physiology)
  • Surveys and Questionnaires
  • Treatment Outcome

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