Abstract | INTRODUCTION: AREAS COVERED: The dual role of LOX-1 as a culprit molecule in the process of atherosclerosis and as a danger signal in various tissues is introduced. The structure of the receptor, its ligands and its modulation by known drugs, by natural products (e.g., statins, imipramine, salicylate-based drugs, procyanidins, curcumin) and by new strategies (antisenseRNA, miRNA, pyrrole-imidazol- polyamides, LOX-1 antibodies, lipid apheresis) are described. EXPERT OPINION: Therapeutic approaches via transcript regulation, allowing a modulation of LOX-1, may be an easier and safer strategy than a blockade of the receptor. Considering the wide distribution of LOX-1 on different tissues, research on the mechanisms of LOX-1 modulation by drugs and natural products applying "omic"-technologies will not only allow a better understanding of the role of LOX-1 in the processes of atherosclerosis, inflammation and longevity but also support the development of specific LOX-1 modulators, avoiding the initiation of molecular mechanisms which lead to adverse events.
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Authors | Gudrun Ulrich-Merzenich, Heike Zeitler |
Journal | Expert opinion on therapeutic targets
(Expert Opin Ther Targets)
Vol. 17
Issue 8
Pg. 905-19
(Aug 2013)
ISSN: 1744-7631 [Electronic] England |
PMID | 23738516
(Publication Type: Journal Article, Review)
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Chemical References |
- Antibodies
- MicroRNAs
- RNA, Antisense
- Scavenger Receptors, Class E
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Topics |
- Animals
- Antibodies
(pharmacology)
- Atherosclerosis
(drug therapy, metabolism)
- Humans
- Inflammation
(metabolism)
- Longevity
- MicroRNAs
(pharmacology)
- RNA, Antisense
(pharmacology)
- Scavenger Receptors, Class E
(metabolism)
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