Tuberous sclerosis presenting with spontaneous pneumothorax secondary to lymphangioleiomyomatosis; previously mistaken for asthma.

Abstract

A middle-aged female patient, previously diagnosed with asthma, presented with a large spontaneous left pneumothorax. She had a history of nephrectomy for a ruptured renal angiomyolipoma (AML) with a postoperative spontaneous pneumothorax when she was an adolescent. High-resolution CT chest revealed multiple scattered thin-walled lung parenchyma cysts consistent with lymphangioleiomyomatosis (LAM). Hepatic AMLs and adenoma sebaceum skin lesions were also noted, consistent with an overall diagnosis of tuberous sclerosis. Her acute management included lung re-expansion via chest tube insertion, antibiotics for concurrent chest infection, nebulisation and chest physiotherapy. Since discharge, the patient had only occasional shortness of breath, relieved by bronchodilators. She is considering expanded immunisation as well as enrolment in a clinical trial. Her hepatic AMLs will be monitored via ultrasound for growth. LAM treatment is generally aimed at its complications with lung transplantation reserved for severe disease; however, hormonal therapy and the mTOR inhibitor aim at targeting systemic disease.

• Authors: Maria Angela Gosein, Anthony Ameeral, Siva Krishna Prasad Konduru, Venkata Naga Srinivas Dola
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2013 (May 31 2013) ISSN: 1757-790X [Electronic] England
• PMID: 23729718 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Diagnosis, Differential
• Female
• Humans
• Lymphangioleiomyomatosis (complications, diagnosis, therapy)
• Pneumothorax (etiology, therapy)
• Tomography, X-Ray Computed
• Treatment Outcome
• Tuberous Sclerosis (complications, diagnosis, therapy)