Effect of insulin therapy on IGF-1 level in children with new-onset type 1 diabetes mellitus: a comparison between DKA and non-DKA.

Abstract

BACKGROUND AND OBJECTIVE:

The issue of insulin-like growth factor 1 (IGF-1) and diabetes in adults and type 2 diabetes has been well investigated. A few studies have investigated the serum IGF-1 level at the onset of type 1 diabetes mellitus (T1DM) in children. In the present study, we investigated the IGF-1 level of T1DM children before and after insulin therapy.

SUBJECTS AND METHODS:

Between August 2011 and October 2012, 62 children with newly diagnosed T1DM were recruited. Serum IGF-1 levels were compared before and 1 month after insulin therapy between diabetic ketoacidosis (DKA) and non-DKA patients.

RESULTS:

Thirty-one patients without DKA (18 girls and 13 boys, mean age 8.8 ± 3.01 years) and 31 patients with DKA (18 girls and 13 boys, mean age 8.3 ± 3.7 years) were studied. The mean IGF-1 in the DKA group was lower than that in the non-DKA group; however, this difference was not statistically significant (p=0.10). Serum IGF-1 levels increased significantly 1 month after insulin therapy in both the DKA (p<0.001) and non-DKA (p<0.001) groups.

CONCLUSION:

Serum IGF-1 level is reduced in new-onset T1DM children. A significant increase in serum IGF-1 level can occur with insulin therapy in both DKA and non-DKA children.

• Authors: Siamak Shiva, Haleh Behbod, Robabeh Ghergherechi
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 26 Issue 9-10 Pg. 883-6 ( 2013) ISSN: 2191-0251 [Electronic] Germany
• PMID: 23729551 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hypoglycemic Agents
• IGF1 protein, human
• Insulin
• Insulin-Like Growth Factor I

Topics

• Adolescent
• Child
• Child Development
• Child, Preschool
• Cross-Sectional Studies
• Diabetes Mellitus, Type 1 (blood, complications, drug therapy)
• Diabetic Ketoacidosis (prevention & control)
• Down-Regulation (drug effects)
• Drug Resistance
• Female
• Hospitals, Pediatric
• Humans
• Hypoglycemic Agents (therapeutic use)
• Infant
• Insulin (therapeutic use)
• Insulin-Like Growth Factor I (analysis)
• Male
• Severity of Illness Index
• Up-Regulation (drug effects)