HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Talc pleurodesis for the management of malignant pleural effusions in Japan.

AbstractOBJECTIVE:
Malignant pleural effusions are commonly treated with tube drainage followed by chemical pleurodesis to maintain the patient's quality of life. While talc is now accepted to be a worldwide gold-standard sclerosing agent for treating malignant pleural effusion, it is not yet approved in Japan. Instead, many patients are administered OK-432 for pleurodesis, which carries the risk of complications such as high-grade fever, chest pain, anaphylactic shock, interstitial pneumonia and acute renal failure. To assess the efficacy and safety of talc as a sclerosing agent in the management of malignant pleural effusions in Japanese patients.
METHODS:
Pleurodesis was performed using 4 g of sterile talc with thoracoscopic talc poudrage or the administration of talc slurry via a chest tube in patients with malignant pleural effusions.
RESULTS:
A total of 57 patients were included. The success rate of pleurodesis assessed on chest radiography at 30, 90 and 180 days was 90.6%, 80.9% and 76.1%, respectively. Complications occurring after talc pleurodesis included fever in 10.5% of the patients and chest pain in 14.0% of the patients. No major complications were reported.
CONCLUSION:
Talc pleurodesis is an effective and safe treatment for the management of malignant pleural effusion in Japanese patients.
AuthorsTakeo Inoue, Atsuko Ishida, Miho Nakamura, Hiroki Nishine, Masamichi Mineshita, Teruomi Miyazawa
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 52 Issue 11 Pg. 1173-6 ( 2013) ISSN: 1349-7235 [Electronic] Japan
PMID23728550 (Publication Type: Journal Article)
Chemical References
  • Talc
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Disease Management
  • Female
  • Humans
  • Japan (epidemiology)
  • Male
  • Middle Aged
  • Pleural Effusion, Malignant (epidemiology, therapy)
  • Pleurodesis (methods)
  • Prospective Studies
  • Talc (administration & dosage)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: