Near-infrared fluorescence goggle system with complementary metal-oxide-semiconductor imaging sensor and see-through display.

Abstract

We have developed a near-infrared (NIR) fluorescence goggle system based on the complementary metal-oxide-semiconductor active pixel sensor imaging and see-through display technologies. The fluorescence goggle system is a compact wearable intraoperative fluorescence imaging and display system that can guide surgery in real time. The goggle is capable of detecting fluorescence of indocyanine green solution in the picomolar range. Aided by NIR quantum dots, we successfully used the fluorescence goggle to guide sentinel lymph node mapping in a rat model. We further demonstrated the feasibility of using the fluorescence goggle in guiding surgical resection of breast cancer metastases in the liver in conjunction with NIR fluorescent probes. These results illustrate the diverse potential use of the goggle system in surgical procedures.

• Authors: Yang Liu, Raphael Njuguna, Thomas Matthews, Walter J Akers, Gail P Sudlow, Suman Mondal, Rui Tang, Viktor Gruev, Samuel Achilefu
• Journal: Journal of biomedical optics (J Biomed Opt) Vol. 18 Issue 10 Pg. 101303 (Oct 2013) ISSN: 1560-2281 [Electronic] United States
• PMID: 23728180 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Topics

• Animals
• Equipment Design
• Eye Protective Devices
• Female
• Histocytochemistry
• Liver Neoplasms (chemistry, surgery)
• Mice
• Mice, Inbred BALB C
• Models, Biological
• Molecular Imaging (instrumentation, methods)
• Quantum Dots
• Rats
• Rats, Sprague-Dawley
• Semiconductors
• Spectroscopy, Near-Infrared (instrumentation, methods)
• Surgery, Computer-Assisted (instrumentation, methods)