D-pantethine has vitamin activity equivalent to d-pantothenic acids for recovering from a deficiency of D-pantothenic acid in rats.

Abstract

D-Pantethine is a compound in which two molecules of D-pantetheine bind through an S-S linkage. D-Pantethine is available from commercial sources as well as from D-pantothenic acid. We investigated if D-pantethine has the same vitamin activity as D-pantothenic acid by comparing the recovery from a deficiency of D-pantothenic acid in rats. D-Pantothenic acid-deficient rats were developed by weaning rats on a diet lacking D-pantothenic acid for 47 d. At that time, the urinary excretion of D-pantothenic acid was almost zero, and the body weight extremely low, compared with the control (p<0.05); the contents of free D-pantothenic acid were also significantly reduced in comparison with those of controls (p<0.05). D-Pantothenic acid-deficient rats were administered a diet containing D-pantothenic acid or D-pantethine for 7 d. D-Pantethine and D-pantothenic acid contents of the diets were equimolar in forms of D-pantothenic acid. We compared various parameters concerning nutritional status between rats fed D-pantothenic acid- and D-pantethine-containing diets. The recoveries of body weight, tissue weights, and tissue concentrations of free D-pantothenic acid, dephospho-CoA, CoA, and acetyl-CoA were identical between rats fed diets containing D-pantothenic acid and D-pantethine. Thus, the biological efficiency for recovering from a deficiency of D-pantothenic acid in rats was equivalent between D-pantothenic acid and D-pantethine.

• Authors: Katsumi Shibata, Mayu Kaneko, Tsutomu Fukuwatari
• Journal: Journal of nutritional science and vitaminology (J Nutr Sci Vitaminol (Tokyo)) Vol. 59 Issue 2 Pg. 93-9 ( 2013) ISSN: 1881-7742 [Electronic] Japan
• PMID: 23727638 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vitamins
• Pantothenic Acid
• dephosphocoenzyme A
• Pantetheine
• Acetyl Coenzyme A
• pantethine
• Coenzyme A

Topics

• Acetyl Coenzyme A (analysis)
• Animals
• Body Weight (drug effects)
• Coenzyme A (analysis)
• Diet
• Male
• Organ Size (drug effects)
• Pantetheine (analogs & derivatives, blood, pharmacology)
• Pantothenic Acid (blood, deficiency, pharmacology)
• Rats
• Rats, Wistar
• Vitamins (blood, pharmacology)
• Weaning