Abstract |
Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti- tumor, anti-microbial, antioxidant, and anti-inflammatory activities. In this study, we investigated the anti-inflammatory mechanisms of BISA in dendritic cells (DCs), which play an essential role in innate and adaptive immune responses. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. Taken together, our data suggest that BISA inhibited DC functions by blocking MAPK and NF-κB signaling.
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Authors | Hyung Sook Kim, Young June Lee, Hong Kyung Lee, Ji Sung Kim, Yunsoo Park, Jong Soon Kang, Bang Yeon Hwang, Jin Tae Hong, Youngsoo Kim, Sang-Bae Han |
Journal | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
(Food Chem Toxicol)
Vol. 59
Pg. 26-33
(Sep 2013)
ISSN: 1873-6351 [Electronic] England |
PMID | 23727177
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Cytokines
- NF-kappa B
- Protein Kinase Inhibitors
- Sesquiterpenes
- bisabolangelone
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Topics |
- Angelica
(chemistry)
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(chemistry, isolation & purification, pharmacology)
- Cells, Cultured
- Cytokines
(metabolism)
- Cytokinesis
(drug effects)
- Dendritic Cells
(cytology, drug effects, immunology, metabolism)
- Endocytosis
(drug effects)
- Ethnopharmacology
- Female
- Lymphocyte Activation
(drug effects)
- MAP Kinase Signaling System
(drug effects)
- Medicine, Korean Traditional
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- NF-kappa B
(antagonists & inhibitors, metabolism)
- Plant Roots
(chemistry)
- Protein Kinase Inhibitors
(chemistry, isolation & purification, pharmacology)
- Republic of Korea
- Sesquiterpenes
(chemistry, isolation & purification, pharmacology)
- T-Lymphocytes
(cytology, drug effects, immunology)
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