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Bisabolangelone inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.

Abstract
Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. In this study, we investigated the anti-inflammatory mechanisms of BISA in dendritic cells (DCs), which play an essential role in innate and adaptive immune responses. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. Taken together, our data suggest that BISA inhibited DC functions by blocking MAPK and NF-κB signaling.
AuthorsHyung Sook Kim, Young June Lee, Hong Kyung Lee, Ji Sung Kim, Yunsoo Park, Jong Soon Kang, Bang Yeon Hwang, Jin Tae Hong, Youngsoo Kim, Sang-Bae Han
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 59 Pg. 26-33 (Sep 2013) ISSN: 1873-6351 [Electronic] England
PMID23727177 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cytokines
  • NF-kappa B
  • Protein Kinase Inhibitors
  • Sesquiterpenes
  • bisabolangelone
Topics
  • Angelica (chemistry)
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (chemistry, isolation & purification, pharmacology)
  • Cells, Cultured
  • Cytokines (metabolism)
  • Cytokinesis (drug effects)
  • Dendritic Cells (cytology, drug effects, immunology, metabolism)
  • Endocytosis (drug effects)
  • Ethnopharmacology
  • Female
  • Lymphocyte Activation (drug effects)
  • MAP Kinase Signaling System (drug effects)
  • Medicine, Korean Traditional
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • NF-kappa B (antagonists & inhibitors, metabolism)
  • Plant Roots (chemistry)
  • Protein Kinase Inhibitors (chemistry, isolation & purification, pharmacology)
  • Republic of Korea
  • Sesquiterpenes (chemistry, isolation & purification, pharmacology)
  • T-Lymphocytes (cytology, drug effects, immunology)

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