Abstract | BACKGROUND: METHODS: We enrolled 32 renal transplant recipients (at least 1 year after transplantation) without prior evidence of diabetes at our institution in this study. Transplant recipients were divided into 2 groups (normal glucose tolerance group and glucose intolerance group) according to the results of their oral glucose tolerance test with 75 g of glucose. Glucose intolerance included IFG, IGT, and IFG/IGT. Normal glucose tolerance was detected in 19 patients, and glucose intolerance in 13: had 6 IGT, 2 IFG, and 5 IGT/IFG. Bilateral brachial-ankle pulse-wave velocity (baPWV) and intimal-media thickness (IMT) measured as markers of atherosclerosis were compared between the 2 groups. Insulin resistance was estimated with the homeostasis model assessment of insulin resistance (HOMA-R), and pancreatic β-cell function evaluated by the homeostasis model assessment of β-cell function and insulinogenic index. RESULTS: The patients in the glucose intolerance group showed significantly greater baPWV and IMT than those in the normal glucose tolerance group. HOMA-R in the glucose intolerance patients was significantly higher than in the normal glucose tolerance patients. Linear regression analysis showed the increased IMT in the renal transplant recipients to be significantly correlated with HOMA-R. CONCLUSIONS:
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Authors | J Uchida, Y Machida, T Iwai, N Kuwabara, K Kabei, T Naganuma, N Kumada, T Nakatani |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 45
Issue 4
Pg. 1535-9
(May 2013)
ISSN: 1873-2623 [Electronic] United States |
PMID | 23726614
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Topics |
- Aged
- Carotid Arteries
(pathology)
- Female
- Glucose Tolerance Test
- Humans
- Islets of Langerhans
(physiopathology)
- Kidney Transplantation
- Male
- Middle Aged
- Pulse Wave Analysis
- Tunica Intima
(pathology)
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