Intrapleural or intraperitoneal lobaplatin for treatment of patients with malignant pleural effusion or ascites.

To explore efficacy and side effects of intrapleural or intraperitoneal lobaplatin for treating patients with malignant pleural or peritoneal effusions.
Patients in Jiangsu Cancer Hospital and Research Institute with cytologically confirmed solid tumors complicated with malignant pleural effusion or ascites were enrolled into this study. Lobaplatin (20-30 mg/m2) was intrapleurally or intraperitoneally infused for patients with malignant pleural effusion or ascites.
From 2012 to 2013, intrapleural or intraperitonea lobaplatin was administered for patients with colorectal or uterus cancer who were previous treated for malignant pleural effusion or ascites. Partial response was achieved for them. Main side effects were nausea/vomiting, and bone marrow suppression. No treatment related deaths occurred.
Intrapleural or intraperitoneal infusion of lobaplatin is a safe treatment for patients with malignant pleural effusion or ascites, and the treatment efficacy is encouraging.
AuthorsXin-En Huang, Guo-Li Wei, Jie-Ge Huo, Xiao-Ning Wang, Yan-Yan Lu, Xue-Yan Wu, Jin Liu, Jin Xiang, Ji-Feng Feng
JournalAsian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 14 Issue 4 Pg. 2611-4 ( 2013) ISSN: 1513-7368 [Print] Thailand
PMID23725184 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Cyclobutanes
  • Organoplatinum Compounds
  • lobaplatin
  • Adenocarcinoma (complications, drug therapy, pathology)
  • Adult
  • Antineoplastic Agents (adverse effects)
  • Ascites (diagnosis, drug therapy, etiology)
  • Cyclobutanes (therapeutic use)
  • Drug Administration Routes
  • Female
  • Humans
  • Injections, Intraperitoneal
  • Liver Neoplasms (complications, drug therapy, secondary)
  • Lung Neoplasms (complications, drug therapy, pathology)
  • Male
  • Middle Aged
  • Organoplatinum Compounds (therapeutic use)
  • Pleural Effusion, Malignant (chemically induced, diagnosis, drug therapy)
  • Prognosis
  • Uterine Cervical Neoplasms (complications, drug therapy, pathology)

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