Abstract |
The study was conducted to determine the effect of Malaysian jungle Tualang Honey (TH) on development of breast cancer induced by the carcinogen 7,12-dimethylbenz(α)anthracene (DMBA) in rats. Forty nulliparous female Sprague-Dawley rats were given 80 mg/kg DMBA then randomly divided into four groups: Group 1 served as a Control while Groups 2, 3 and 4 received 0.2, 1.0 or 2.0 g/kg bodyweight/day of TH, respectively, for 150 days. Results showed that breast cancers in the TH-treated groups had slower size increment and smaller mean tumor size (≤ 2 cm3) compared to Controls (≤ 8 cm3). The number of cancers developing in TH-treated groups was also significantly fewer (P<0.05). Histological grading showed majority of TH-treated group cancers to be of grade 1 and 2 compared to grade 3 in controls. There was an increasing trend of apoptotic index (AI) seen in TH-treated groups with increasing dosage of Tualang Honey, however, the mean AI values of all TH-treated groups were not significantly different from the Control value (p>0.05). In conclusion, Tualang Honey exerted positive modulation effects on DMBA-induced breast cancers in rats in this preliminary study.
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Authors | Erazuliana Abd Kadir, Siti Amrah Sulaiman, Nurul Khaiza Yahya, Nor Hayati Othman |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 14
Issue 4
Pg. 2249-54
( 2013)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 23725121
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carcinogens
- Vascular Endothelial Growth Factor A
- vascular endothelial growth factor A, rat
- 9,10-Dimethyl-1,2-benzanthracene
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Topics |
- 9,10-Dimethyl-1,2-benzanthracene
(toxicity)
- Animals
- Apoptosis
(drug effects)
- Blotting, Western
- Carcinogens
(toxicity)
- Cell Proliferation
- Female
- Honey
(statistics & numerical data)
- Mammary Neoplasms, Experimental
(chemically induced, pathology, prevention & control)
- Rats
- Rats, Sprague-Dawley
- Vascular Endothelial Growth Factor A
(metabolism)
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