Population in an industrialized world is afflicted by
urinary stone disease.
Kidney stones are common in all kinds of
urolithiasis. One distinguished formulation mentioned by Sushruta for management of Ashmari (
urolithiasis) is Pashanabhedadi Ghrita (PBG), which is in clinical practice since centuries. Validation of
drug is the requirement of time through the experimental study. In this study, trial of PBG has been made against
ammonium oxalate rich diet and
gentamicin injection induced
renal calculi in albino rats. The
calculi were induced by
gentamicin injection and
ammonium oxalate rich diet. Test
drug was administered concomitantly in the dose
of 900 mg/kg for 15 consecutive days. Rats were sacrificed on the 16(th) day. Parameters like kidney weight, serum biochemical, kidney tissue and histopathology of kidney were studied. Concomitant treatment of PBG attenuates blood biochemical parameters non-significantly, where as it significantly attenuated lipid peroxidation and enhanced
glutathione and
glutathione peroxidase activities. It also decreased crystal deposition markedly into the renal tubules in number as well as size and prevented damage to the renal tubules. The findings showed that PBG is having significant anti-urolithiatic activities against
ammonium oxalate rich diet plus gentamicine injection induced
urolithiasis in rats.