Abstract | OBJECTIVE: APPROACH AND RESULTS: Four thousand one hundred fifty patients (72% men; median age 62 years) were included. Plasma dimethylglycine was associated with several traditional coronary artery disease risk factors. During a median follow-up of 4.6 years, 343 (8.3%) patients experienced an acute myocardial infarction. The hazard ratio (95% confidence interval) for acute myocardial infarction was 1.95 (1.42-2.68; P<0.001) when comparing plasma dimethylglycine quartile 4 to 1 in a Cox regression model adjusted for age, sex, and fasting status. Adjusting for traditional coronary artery disease risk factors only slightly modified the estimates, which were particularly strong among nonsmokers and among patients with serum triglyceride or apolipoprotein B100 levels ≤ median (P for interaction=0.004, 0.004, and 0.03, respectively). Plasma dimethylglycine improved discrimination and reclassification and had high test-retest reliability. CONCLUSIONS:
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Authors | Gard Frodahl Tveitevåg Svingen, Per Magne Ueland, Eva Kristine Ringdal Pedersen, Hall Schartum-Hansen, Reinhard Seifert, Marta Ebbing, Kjetil Halvorsen Løland, Grethe S Tell, Ottar Nygård |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 33
Issue 8
Pg. 2041-8
(Aug 2013)
ISSN: 1524-4636 [Electronic] United States |
PMID | 23723367
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- dimethylglycine
- Sarcosine
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Topics |
- Adult
- Aged
- Angina, Stable
(blood, epidemiology)
- Biomarkers
(blood)
- Energy Metabolism
(physiology)
- Female
- Follow-Up Studies
- Humans
- Incidence
- Kaplan-Meier Estimate
- Lipid Metabolism
(physiology)
- Male
- Middle Aged
- Myocardial Infarction
(blood, epidemiology)
- Predictive Value of Tests
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Sarcosine
(analogs & derivatives, blood)
- Thrombosis
(blood, epidemiology)
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