Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin-globotriose hybrids.

Abstract

Designed and synthesized porphyrin-globotriose hybrids effectively degraded verotoxin-1, which causes severe bloody diarrhoea and fetal hemolytic uremic syndrome (HUS). Degradation was achieved using long-wavelength UV or visible light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrids neutralized the cytotoxicity of verotoxin upon photo-irradiation.

• Authors: Atsushi Okochi, Shuho Tanimoto, Daisuke Takahashi, Kazunobu Toshima
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 49 Issue 54 Pg. 6027-9 (Jul 11 2013) ISSN: 1364-548X [Electronic] England
• PMID: 23722161 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Porphyrins
• Shiga Toxin 1
• Trisaccharides
• globotriose

Topics

• Animals
• Cell Survival (drug effects)
• Chlorocebus aethiops
• Light
• Photolysis
• Porphyrins (chemistry)
• Shiga Toxin 1 (metabolism, toxicity)
• Trisaccharides (chemistry)
• Ultraviolet Rays
• Vero Cells