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The synthesis of neurotensin antagonist SR 48692 for prostate cancer research.

Abstract
An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.
AuthorsI R Baxendale, S Cheung, M O Kitching, S V Ley, J W Shearman
JournalBioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 21 Issue 14 Pg. 4378-87 (Jul 15 2013) ISSN: 1464-3391 [Electronic] England
PMID23721919 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
Chemical References
  • Pyrazoles
  • Quinolines
  • SR 48692
  • Neurotensin
Topics
  • Cell Line, Tumor
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Molecular Structure
  • Neurotensin (antagonists & inhibitors)
  • Prostatic Neoplasms (drug therapy)
  • Pyrazoles (chemical synthesis, chemistry)
  • Quinolines (chemical synthesis, chemistry)

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