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Post-staphylococcal infection Henoch-Schönlein purpura nephritis: a case report and review of the literature.

Abstract
A 37-year-old man developed Henoch--Schönlein purpura nephritis (HSPN) with nephrotic syndrome and rapidly progressive glomerulonephritis after otitis media and externa due to methicillin-resistant Staphylococcus aureus infection. Despite resolution of the infection and prednisolone therapy, his kidney disease worsened. However, the addition of cyclosporine A finally resulted in complete remission of the nephrotic syndrome. A review of similar cases with post-Staphylococcal infection HSPN revealed strong similarities between this entity and immunoglobulin A-dominant postinfectious glomerulonephritis (IgA-PIGN), an increasingly recognized form of PIGN typically associated with Staphylococcal infection, in both clinical and morphological features. Post-Staphylococcal infection HSPN may constitute a subgroup of IgA-PIGN.
AuthorsShintaro Mandai, Makoto Aoyagi, Kiyotaka Nagahama, Yohei Arai, Suguru Hirasawa, Shota Aki, Naoto Inaba, Hiroyuki Tanaka, Yukio Tsuura, Teiichi Tamura, Sei Sasaki
JournalRenal failure (Ren Fail) Vol. 35 Issue 6 Pg. 869-74 (Jul 2013) ISSN: 1525-6049 [Electronic] England
PMID23721509 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Glucocorticoids
  • Immunosuppressive Agents
  • Cyclosporine
  • Prednisolone
Topics
  • Adult
  • Cyclosporine (therapeutic use)
  • Glomerulonephritis (drug therapy, etiology, microbiology)
  • Glucocorticoids (therapeutic use)
  • Humans
  • IgA Vasculitis (complications, microbiology)
  • Immunosuppressive Agents (therapeutic use)
  • Male
  • Methicillin-Resistant Staphylococcus aureus
  • Prednisolone (therapeutic use)
  • Staphylococcal Infections (complications, microbiology)

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