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[Effect of homocysteine on left ventricular structural and functional parameters in patients on programmed hemodialysis].

AbstractAIM:
To determine the effect of plasma homocysteine (Hc) on the structure and function of the left ventricle (LV) in patients treated by programmed hemodialysis.
SUBJECTS AND METHODS:
109 patients on programmed hemodialysis were examined. Blood Hc levels were determined and echocardiography was performed in all the patients.
RESULTS:
In the patients on programmed hemodialysis, Hc concentrations were significantly higher than in apparently healthy individuals; there was a preponderance of mild (49.5%) and moderate (43.1%) hyperhomocysteinemia. LV hypertrophy was diagnosed in 90.8% of the patients. A positive relationship was found between the concentrations of Hc and the E/A ratio (r = 0.34; p = 0.05), isovolumetric relaxation time (IRT) (r = 0.32; p = 0.03), and LV mass (LVM) (r = 0.3; p = 0.05). Multivariate regression analysis indicated that the level of Hc had an independent impact on the E peak (R2 = 0.3; p = 0.05), LV relative wall thickness (RWT) (R2 = 0.38; p = 0.03), and LV IRT (R2 = 0.3; p = 0.06).
CONCLUSION:
Elevated plasma Hc levels were found to be related to LVM, LV RWT, LV IRT, E peak, and E/A ratio, suggesting that Hc had an unfavorable effect on the LV structure and function in patients on hemodialysis.
AuthorsU V Kharlamova, O E Il'icheva
JournalTerapevticheskii arkhiv (Ter Arkh) Vol. 85 Issue 3 Pg. 90-3 ( 2013) ISSN: 0040-3660 [Print] Russia (Federation)
PMID23720850 (Publication Type: Journal Article)
Chemical References
  • Homocysteine
Topics
  • Adult
  • Female
  • Heart Ventricles (chemistry, diagnostic imaging, physiopathology)
  • Homocysteine (blood, physiology)
  • Humans
  • Hyperhomocysteinemia (physiopathology)
  • Hypertrophy, Left Ventricular (blood, diagnostic imaging, physiopathology)
  • Male
  • Middle Aged
  • Renal Dialysis (adverse effects)
  • Structure-Activity Relationship
  • Ultrasonography
  • Ventricular Remodeling (physiology)

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