Abstract | OBJECTIVE: ANIMALS: 1,049 weaned crossbred beef calves. PROCEDURES: At each of 6 feedlots, newly arrived calves with BRDC were administered a single dose of gamithromycin (6.0 mg/kg, SC; n = 523) or tulathromycin (2.5 mg/kg, SC; 526). Case-fatality and BRDC retreatment rates during the first 120 days after treatment, final body weight, and average daily gain (ADG), were compared between treatments. At 2 feedlots, calves were assigned clinical scores for 10 days after treatment to determine recovery rates for each treatment. Bioequivalence limits for gamithromycin and tulathromycin were calculated for outcomes for which there was no significant difference between treatments. RESULTS: CONCLUSIONS AND CLINICAL RELEVANCE: Calves administered gamithromycin had a higher BRDC retreatment rate than did calves administered tulathromycin; otherwise, the clinical efficacy did not differ between the 2 treatments for the treatment of BRDC in feedlot calves.
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Authors | Siddartha Torres, Dan U Thomson, Nora M Bello, Bruce J Nosky, Chris D Reinhardt |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 74
Issue 6
Pg. 847-53
(Jun 2013)
ISSN: 1943-5681 [Electronic] United States |
PMID | 23718652
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Disaccharides
- Heterocyclic Compounds
- Macrolides
- tulathromycin
- gamithromycin
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Topics |
- Animals
- Anti-Bacterial Agents
(pharmacology)
- Bovine Respiratory Disease Complex
(prevention & control)
- Cattle
- Disaccharides
(pharmacology)
- Heterocyclic Compounds
(pharmacology)
- Housing, Animal
- Macrolides
(pharmacology)
- Male
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