Normalization of creatine kinase values in a case of rhabdomyolysis during daptomycin treatment.

Abstract

A 41-year-old woman presented in the Emergency Department with suspected compartment syndrome of lower left leg (creatine kinase [CK]: 12,502 IU/L, Cr: 4.31 mg/dL). Fasciotomy of the four limb compartments was conducted. By day 2, the patient presented oliguria during previous 24 h, so daily intermittent dialysis was carried out. On day 12, the patient presented an episode of bacteremia due to Staphylococcus hominis. Treatment with vancomycin was initiated and was changed after 4 days to daptomycin due to unsatisfactory clinical progression (6 mg/kg every 48 h, according to renal function and patient's weight) (CK: 2,972 IU/L). After 15 days of treatment, the dose of daptomycin was increased to 6 mg/kg every 24 h (CrCL: 46 mL/min, CK: 83 IU/L). The antibiotic was continued for another 4 days. Fourteen days later, the patient was discharged (CK: 26 IU/L). Daptomycin could be prescribed in some patients with elevated CK values. A cut-off value of baseline CK for use of daptomycin needs to be determined.

• Authors: Olivia Ferrández, Olatz Urbina, Sònia Luque, Mercè Espona, Nuria Berenguer, Santiago Grau
• Journal: Indian journal of pharmacology (Indian J Pharmacol) 2013 Mar-Apr Vol. 45 Issue 2 Pg. 193-4 ISSN: 1998-3751 [Electronic] India
• PMID: 23716901 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Vancomycin
• Creatine Kinase
• Daptomycin

Topics

• Adult
• Anti-Bacterial Agents (administration & dosage)
• Bacteremia (drug therapy)
• Creatine Kinase (blood)
• Daptomycin (administration & dosage)
• Dose-Response Relationship, Drug
• Female
• Humans
• Rhabdomyolysis (drug therapy, enzymology)
• Staphylococcal Infections (drug therapy)
• Staphylococcus hominis (isolation & purification)
• Treatment Outcome
• Vancomycin (administration & dosage)