Potassium content of irradiated packed red blood cells in different storage media: is there a need for additive solution-dependent recommendations for infant transfusion?

Abstract

Prevention of transfusion-associated graft versus host disease (TA-GVHD) by gamma irradiation is known to induce increased K+ in supernatant of packed red blood cells (PRBCs) stored in CPDA-1 and SAGM conservative solutions. However, no data exist for PRBCs in AS-3 medium which is considered safe for neonatal transfusion. We evaluated haemolysis and K+ release from irradiated AS-3 PRBCs and compared our results with reported data for SAGM and CPDA-1 PRBCs. Our results indicate that irradiated PRBCs stored in AS-3 after more than 7 days post-irradiation should not be used in massive and/or rapidly infused transfusions in neonates and infants.

• Authors: H El Kenz, F Corazza, P Van Der Linden, S Chabab, C Vandenvelde
• Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 49 Issue 2 Pg. 249-53 (Oct 2013) ISSN: 1473-0502 [Print] England
• PMID: 23711835 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• ADSOL
• CPDA solutions
• Citrates
• Cryoprotective Agents
• Phosphates
• Mannitol
• Sodium Chloride
• Glucose
• Adenine
• Potassium

Topics

• Adenine (pharmacology)
• Blood Preservation
• Citrates (pharmacology)
• Cryoprotective Agents (pharmacology)
• Erythrocyte Transfusion
• Erythrocytes (cytology, metabolism)
• Gamma Rays
• Glucose (pharmacology)
• Graft vs Host Disease (prevention & control)
• Hemolysis (drug effects, radiation effects)
• Humans
• Mannitol (pharmacology)
• Phosphates (pharmacology)
• Potassium (metabolism)
• Sodium Chloride (pharmacology)
• Time Factors