miR-155 is involved in tumor progression of mycosis fungoides.

Abstract

Biopsy specimens from 23 early stage and 19 tumor-stage mycosis fungoides (MF) patients were evaluated for miR-155 expression by real-time qualitative PCR and compared with 15 biopsy specimens from patients with T-cell-rich inflammatory skin diseases. Significant upregulation of miR-155 was found in MF tumors compared with both early-stage MF lesions and controls. There was no difference in miR-155 expression between early-stage and inflammatory dermatoses. Using laser capture microdissection, it was found that miR-155 was significantly higher in the lymphoma cells in tumor stage compared with the intraepidermal lymphocytes in early stage. In contrast, there was no difference in miR-155 expression between the intraepidermal lymphocytes and the dermal lymphocytes in early-stage MF. These findings suggest that although miR-155 expression cannot serve to discriminate early-stage MF from inflammatory dermatoses; however, it is involved in the switch from the indolent early stage into the aggressive tumor stage of the disease.

• Authors: Lilach Moyal, Aviv Barzilai, Batia Gorovitz, Avi Hirshberg, Ninette Amariglio, Jasmine Jacob-Hirsch, Leah Maron, Meora Feinmesser, Emmilia Hodak
• Journal: Experimental dermatology (Exp Dermatol) Vol. 22 Issue 6 Pg. 431-3 (Jun 2013) ISSN: 1600-0625 [Electronic] Denmark
• PMID: 23711069 (Publication Type: Comparative Study, Letter)
• Copyright: © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• MIRN155 microRNA, human
• MicroRNAs

Topics

• Adult
• Aged
• Aged, 80 and over
• Biopsy
• Disease Progression
• Female
• Gene Expression Regulation
• Gene Expression Regulation, Neoplastic
• Humans
• Inflammation (pathology)
• Laser Capture Microdissection
• Lymphocytes (metabolism)
• Lymphoma (metabolism)
• Male
• MicroRNAs (metabolism)
• Middle Aged
• Mycosis Fungoides (metabolism)
• Real-Time Polymerase Chain Reaction
• Skin (pathology)
• Skin Diseases
• Skin Neoplasms (metabolism)
• T-Lymphocytes (cytology, metabolism)
• Up-Regulation