Chryseobacterium indologenes central nervous system infection in infancy: an emergent pathogen?

Abstract

The isolation of Chryseobacterium indologenes as a causative micro-organism in human diseases is rare. Risk factors for infections caused by this pathogen include very young and very old age, indwelling devices, immune suppression and recent use of broad-spectrum antibiotics. Most cases suffer from bacteraemia or nosocomial pneumonia, whilst infection of the central nervous system (CNS) is extremely rare. We present a term-born infant diagnosed prenatally with holoprosencephaly and obstructive hydrocephalus, requiring post-natal ventriculoperitoneal shunt insertion. At 6 weeks of age, he suffered from Escherichia coli meningitis, showing satisfactory clinical response with antimicrobial therapy. Aged 11 months, he suffered from hyper-drainage syndrome, resulting in the removal of the shunt system. He represented 11 days post-operatively, with low-grade fever, irritability and cerebrospinal fluid (CSF) leakage. C. indologenes from CSF was isolated and antimicrobial therapy with ceftazidime and trimethoprim-sulfamethoxazole for 3 weeks resulted in good clinical response. This is the first documented community-acquired CNS infection due to C. indologenes in an infant without concomitant indwelling device or previous antibiotic pressure.

• Authors: P Olbrich, M Rivero-Garvía, M D Falcón-Neyra, J A Lepe, J M Cisneros, J Marquez-Rivas, O Neth
• Journal: Infection (Infection) Vol. 42 Issue 1 Pg. 179-83 (Feb 2014) ISSN: 1439-0973 [Electronic] Germany
• PMID: 23709293 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Trimethoprim, Sulfamethoxazole Drug Combination
• Ceftazidime

Topics

• Anti-Bacterial Agents (therapeutic use)
• Ceftazidime (therapeutic use)
• Central Nervous System Infections (diagnosis, drug therapy, microbiology)
• Cerebrospinal Fluid (microbiology)
• Chryseobacterium (isolation & purification)
• Communicable Diseases, Emerging (diagnosis, drug therapy, microbiology)
• Community-Acquired Infections (diagnosis, drug therapy, microbiology)
• Flavobacteriaceae Infections (diagnosis, drug therapy, microbiology)
• Humans
• Infant
• Male
• Treatment Outcome
• Trimethoprim, Sulfamethoxazole Drug Combination (therapeutic use)