Transcatheter arterial embolization using imipenem/cilastatin sodium for tendinopathy and enthesopathy refractory to nonsurgical management.

Abstract

PURPOSE:

To evaluate the feasibility and effects of transcatheter arterial embolization with imipenem/cilastatin sodium (CS) to treat tendinopathy and enthesopathy that are refractory to traditional nonsurgical management.

MATERIALS AND METHODS:

Transcatheter arterial embolization with imipenem/CS as an embolic agent was performed in seven patients (five men; mean age, 51.7 y) with tendinopathy and enthesopathy (patellar tendinopathy, n = 1; rotator cuff tendinopathy, n = 2; plantar fasciitis, n = 1; lateral epicondylitis, n = 1; iliotibial band syndrome, n = 1; and Achilles insertion tendinopathy, n = 1). All patients had unrelenting pain at the site of tendinopathy and enthesopathy before the procedure. Technical success, adverse events, and changes in visual analog scale (VAS) scores were assessed.

RESULTS:

All procedures were technically successful, and no major adverse events developed. Compared with before the procedure, mean VAS scores were significantly decreased at 1 day, 1 week, and 1 and 4 months after the procedure (72.7 mm±9.9 vs 17.4 mm±18.5, 16.0 mm±18.1, 13.7 mm±7.3, and 9.7 mm±6.8, respectively; all P< .001).

CONCLUSIONS:

Transcatheter arterial embolization with imipenem/CS was feasible and effectively relieved unrelenting pain associated with tendinopathy and enthesopathy.

• Authors: Yuji Okuno, Noboru Matsumura, Sota Oguro
• Journal: Journal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) Vol. 24 Issue 6 Pg. 787-92 (Jun 2013) ISSN: 1535-7732 [Electronic] United States
• PMID: 23707086 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright © 2013 SIR. Published by Elsevier Inc. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Drug Combinations
• Hemostatics
• Protease Inhibitors
• Cilastatin
• Imipenem
• Cilastatin, Imipenem Drug Combination

Topics

• Adult
• Aged
• Anti-Bacterial Agents (administration & dosage)
• Arthralgia (diagnosis, drug therapy, etiology)
• Catheterization, Peripheral (methods)
• Chronic Disease
• Cilastatin (administration & dosage)
• Cilastatin, Imipenem Drug Combination
• Drug Combinations
• Embolization, Therapeutic (methods)
• Female
• Hemostatics (administration & dosage)
• Humans
• Imipenem (administration & dosage)
• Male
• Middle Aged
• Pain Measurement (drug effects)
• Protease Inhibitors (administration & dosage)
• Rheumatic Diseases (complications, diagnosis, drug therapy)
• Tendinopathy (complications, diagnosis, drug therapy)
• Treatment Outcome