A randomized controlled clinical trial on the clinical and microbiological efficacy of systemic satranidazole in the treatment of chronic periodontitis.

Abstract

OBJECTIVE:

The present clinical trial was designed to investigate the effectiveness of systemic satranidazole (SZ) as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis.

METHODS:

Sixty-six subjects presenting with at least twelve teeth with probing depth (PD) > or = 4 mm were selected. Thirty-three subjects were randomly assigned to full-mouth SRP + placebo (Group 1) and 33 subjects were assigned to full-mouth SRP + SZ (Group 2). The clinical outcomes evaluated were plaque index (PI), gingival index (GI), clinical attachment level (CAL) and PD at baseline, 1 month, 3 months and 6 months. Also, microbial analysis of dental plaque using polymerase chain reaction was done at baseline, 3 and 6 months to estimate the number of sites harboring periodontopathogens.

RESULTS:

Sixty subjects were evaluated up to 6 months. At 6 months, Group 2 showed greater mean reduction (3.84 +/- 1.31 mm) in PD as compared to Group 1 (1.42 +/- 1.01 mm; p < 0.05) and there was a greater mean CAL gain (3.22 +/- 1.01 mm) in Group 2 as compared to Group 1 (1.15 +/- 1.49 mm; p < 0.05). These subjects also showed significant reductions in the number of certain periodontopathogens, such as Tannerella forsythia, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.

CONCLUSION:

The systemic use of SZ, when used as an adjunct to non-surgical periodontal therapy in subjects with periodontitis, achieves significantly better clinical and microbiological results than scaling and root planing alone.

• Authors: A R Pradeep, N Priyanka, Nitish Kalra, Savitha B Naik
• Journal: Journal of the International Academy of Periodontology (J Int Acad Periodontol) Vol. 15 Issue 2 Pg. 43-50 (Apr 2013) ISSN: 1466-2094 [Print] England
• PMID: 23705535 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Nitroimidazoles
• Placebos
• satranidazole

Topics

• Adult
• Aggregatibacter actinomycetemcomitans (drug effects)
• Anti-Bacterial Agents (therapeutic use)
• Bacterial Load
• Bacteroides (drug effects)
• Chronic Periodontitis (drug therapy, therapy)
• Combined Modality Therapy
• Dental Plaque (microbiology)
• Dental Plaque Index
• Dental Scaling (methods)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Nitroimidazoles (therapeutic use)
• Periodontal Attachment Loss (drug therapy, therapy)
• Periodontal Index
• Periodontal Pocket (drug therapy, therapy)
• Placebos
• Polymerase Chain Reaction
• Porphyromonas gingivalis (drug effects)
• Root Planing (methods)
• Treatment Outcome