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Efficacy and limitations of pulse cyclophosphamide therapy in polymyositis and dermatomyositis.

AbstractOBJECTIVES:
To assess the therapeutic response of intravenous (IV) pulse cyclophosphamide therapy in polymyositis and dermatomyositis.
METHODS:
Data of 9 patients (M:F = 2:7) who received IV pulse cyclophosphamide therapy were retrospectively analyzed.
RESULTS:
The mean symptom duration was 11.33 ± 10.6 months (range, 2-34 months). The cohort comprised (1) primary idiopathic polymyositis (n = 1), (2) primary idiopathic dermatomyositis (n = 1), (3) childhood type associated with vasculitis (n = 1), and (4) associated with collagen vascular disease (n = 6). All patients improved and became clinically asymptomatic after a mean period of 12.33 ± 6.5 months (range, 4-24 months); 5 remained asymptomatic at the end of a median follow-up period of 22 months. All patients received concomitant steroid therapy, and in 6, steroids could be tapered after the initiation of IV pulse cyclophosphamide therapy.
CONCLUSIONS:
In this cohort of polymyositis/dermatomyositis, treatment with IV pulse cyclophosphamide was associated with improvement; the therapeutic response was sustained in majority of the patients.
AuthorsM Nagappa, A B Taly, S Sinha, N Gayathri, P S Bindu, A Mahadevan, T Yasha
JournalJournal of clinical neuromuscular disease (J Clin Neuromuscul Dis) Vol. 14 Issue 4 Pg. 161-8 (Jun 2013) ISSN: 1537-1611 [Electronic] United States
PMID23703010 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Immunosuppressive Agents
  • Cyclophosphamide
  • Desonide
Topics
  • Adolescent
  • Adult
  • Anti-Inflammatory Agents (therapeutic use)
  • Cohort Studies
  • Cyclophosphamide (therapeutic use)
  • Dermatomyositis (complications, drug therapy)
  • Desonide (therapeutic use)
  • Female
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Male
  • Middle Aged
  • Polymyositis (complications, drug therapy)
  • Young Adult

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