Abstract |
Cortactin is an F-actin binding protein involved in cell migration and tumor metastasis. Recent reports suggest that silent mating-type information regulation 2 homologue 1 (sirtuin1; SIRT1) enhances the function of cortactin and promotes cell migration. We investigated SIRT1 and cortactin expression in 144 invasive non-small cell lung cancers (NSCLC) and 19 adenocarcinomas in situ (AIS) by immunohistochemistry and evaluated their clinicopathological significance in NSCLC. Positive SIRT1 and cortactin expression was observed in 67% (96 of 144) and 58% (84 of 144) of patients with invasive NSCLC, respectively. SIRT1 and cortactin expression was significantly associated with unfavorable clinicopathological factors, including high pathological T stage, lymph node metastasis, and advanced tumor invasion (AIS vs. invasive adenocarcinoma). Cortactin was significantly associated with high pathological T stage and lymph node metastasis in SIRT1-positive tumors. Cytoplasmic SIRT1 was significantly associated with high pathological T stage and large tumor size compared to that of nuclear SIRT1. Large tumor size, high pathological T stage, lymph node metastasis, and cytoplasmic SIRT1 expression were significantly associated with shorter overall survival in a univariate analysis. Our findings suggest that SIRT1 and cortactin may play a role in the progression of NSCLC and may cooperate during tumor progression in NSCLC.
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Authors | Sang Jae Noh, Hyun Ah Baek, Ho Sung Park, Kyu Yun Jang, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee, Min Ho Kim, Ju Hyung Lee, Myoung Ja Chung |
Journal | Pathology, research and practice
(Pathol Res Pract)
Vol. 209
Issue 6
Pg. 365-70
(Jun 2013)
ISSN: 1618-0631 [Electronic] Germany |
PMID | 23702379
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier GmbH. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- CTTN protein, human
- Cortactin
- SIRT1 protein, human
- Sirtuin 1
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Topics |
- Adenocarcinoma
(enzymology, mortality, pathology)
- Adenocarcinoma of Lung
- Adult
- Aged
- Biomarkers, Tumor
(analysis)
- Carcinoma in Situ
(enzymology, mortality, pathology)
- Carcinoma, Non-Small-Cell Lung
(enzymology, mortality, secondary)
- Carcinoma, Squamous Cell
(enzymology, mortality, secondary)
- Cortactin
(analysis)
- Cytoplasm
(enzymology)
- Disease Progression
- Female
- Humans
- Immunohistochemistry
- Lung Neoplasms
(enzymology, mortality, pathology)
- Lymphatic Metastasis
- Male
- Middle Aged
- Multivariate Analysis
- Neoplasm Invasiveness
- Neoplasm Staging
- Predictive Value of Tests
- Prognosis
- Proportional Hazards Models
- Risk Factors
- Sirtuin 1
(analysis)
- Time Factors
- Tumor Burden
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