Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.

Abstract

Cortactin is an F-actin binding protein involved in cell migration and tumor metastasis. Recent reports suggest that silent mating-type information regulation 2 homologue 1 (sirtuin1; SIRT1) enhances the function of cortactin and promotes cell migration. We investigated SIRT1 and cortactin expression in 144 invasive non-small cell lung cancers (NSCLC) and 19 adenocarcinomas in situ (AIS) by immunohistochemistry and evaluated their clinicopathological significance in NSCLC. Positive SIRT1 and cortactin expression was observed in 67% (96 of 144) and 58% (84 of 144) of patients with invasive NSCLC, respectively. SIRT1 and cortactin expression was significantly associated with unfavorable clinicopathological factors, including high pathological T stage, lymph node metastasis, and advanced tumor invasion (AIS vs. invasive adenocarcinoma). Cortactin was significantly associated with high pathological T stage and lymph node metastasis in SIRT1-positive tumors. Cytoplasmic SIRT1 was significantly associated with high pathological T stage and large tumor size compared to that of nuclear SIRT1. Large tumor size, high pathological T stage, lymph node metastasis, and cytoplasmic SIRT1 expression were significantly associated with shorter overall survival in a univariate analysis. Our findings suggest that SIRT1 and cortactin may play a role in the progression of NSCLC and may cooperate during tumor progression in NSCLC.

• Authors: Sang Jae Noh, Hyun Ah Baek, Ho Sung Park, Kyu Yun Jang, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee, Min Ho Kim, Ju Hyung Lee, Myoung Ja Chung
• Journal: Pathology, research and practice (Pathol Res Pract) Vol. 209 Issue 6 Pg. 365-70 (Jun 2013) ISSN: 1618-0631 [Electronic] Germany
• PMID: 23702379 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier GmbH. All rights reserved.

Chemical References

• Biomarkers, Tumor
• CTTN protein, human
• Cortactin
• SIRT1 protein, human
• Sirtuin 1

Topics

• Adenocarcinoma (enzymology, mortality, pathology)
• Adenocarcinoma of Lung
• Adult
• Aged
• Biomarkers, Tumor (analysis)
• Carcinoma in Situ (enzymology, mortality, pathology)
• Carcinoma, Non-Small-Cell Lung (enzymology, mortality, secondary)
• Carcinoma, Squamous Cell (enzymology, mortality, secondary)
• Cortactin (analysis)
• Cytoplasm (enzymology)
• Disease Progression
• Female
• Humans
• Immunohistochemistry
• Lung Neoplasms (enzymology, mortality, pathology)
• Lymphatic Metastasis
• Male
• Middle Aged
• Multivariate Analysis
• Neoplasm Invasiveness
• Neoplasm Staging
• Predictive Value of Tests
• Prognosis
• Proportional Hazards Models
• Risk Factors
• Sirtuin 1 (analysis)
• Time Factors
• Tumor Burden