[The correction with hepatic protectors of structural metabolic disorders in the liver in D-galactosamine poisoning].

Abstract

The hepatoprotective agents silybinin, essentiale and eplir (the complex of phospholipids and caratinoids from the mud) prevent in D-galactosamine-induced intoxication of rats the development of hepatitis, hepatocyte necrosis, a decrease in hepatocytes of the activity of the enzymes of mitochondria and endoplasmic reticulum, labilization of lysosomes. These drugs stimulate D-galactosamine-suppressed antitoxic function of the liver: they increase the contents of RNA, cytochromes P-450, b5, the activity of amidopyrine-D-demethylase, hydroxylases of hexobarbital and aniline, improve the activity of the respiratory chain of microsomes, counteract inactivation of cytochrome P-450 into cytochrome P-420. Essentiale and eplir activate conjugation of xenobiotics with reduced glutathione.

• Authors: A S Saratikov, A I Vengerovskiĭ, I M Sedykh
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1990 Mar-Apr Vol. 53 Issue 2 Pg. 38-40 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Korrektsiia gepatoprotektorami strukturno-metabolicheskikh narusheniĭ v pecheni pri intoksikatsii D-galaktozaminom.
• PMID: 2369952 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antidotes
• Drug Combinations
• Flavonoids
• Phosphatidylcholines
• Phospholipids
• Silymarin
• eplir
• essential 303 forte
• Carotenoids
• Galactosamine

Topics

• Animals
• Antidotes (therapeutic use)
• Carotenoids (therapeutic use)
• Drug Combinations (therapeutic use)
• Drug Evaluation, Preclinical
• Flavonoids (therapeutic use)
• Galactosamine (poisoning)
• Liver (drug effects, metabolism, pathology)
• Male
• Mud Therapy
• Phosphatidylcholines (therapeutic use)
• Phospholipids (therapeutic use)
• Rats
• Silymarin (therapeutic use)