[An experimental and clinical study of the analgesic action of clofelin when administered epidurally].

Abstract	Clonidine and its Soviet-made analogue clopheline (10 micrograms) after epidural administration to rats equally inhibited nociceptive reactions and changes in arterial blood pressure in the somatic and visceral pain tests. In patients with obliterating atherosclerosis of the lower extremities clopheline (100 and 200 micrograms) relieved the pain syndrome and shifts of II-hydroxycorticosteroids in blood, induced bradycardia and the background arterial blood pressure-dependent antihypertensive effect.
Authors	Iu D Ignatov, A A Zaĭtsev, V I Strashnov, M Dzhaberi, V I Khnykina
Journal	Farmakologiia i toksikologiia (Farmakol Toksikol) 1990 Mar-Apr Vol. 53 Issue 2 Pg. 17-20 ISSN: 0014-8318 [Print] Russia (Federation)
Vernacular Title	Eksperimental'no-klinicheskoe izuchenie boleutoliaiushchego deĭstviia klofelina pri épidural'nom vvedenii.
PMID	2369946 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References	Clonidine
Topics	Adult Aged Analgesia, Epidural (methods) Animals Arteriosclerosis Obliterans (physiopathology, therapy) Clonidine (administration & dosage, pharmacology) Dose-Response Relationship, Drug Drug Evaluation Drug Evaluation, Preclinical Hemodynamics (drug effects) Humans Male Middle Aged Preoperative Care Rats

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