Protection of mice against lipopolysaccharide-induced endotoxic shock by pinocembrin is correlated with regulation of cytokine secretion.

Abstract

Natural products have been used as potentially important sources of anti-inflammatory drugs. This study examined the effects of pinocembrin against lipopolysaccharide (LPS)-induced endotoxemia to ascertain whether pinocembrin could protect mice from ensuing death. Cytokine responses were also assessed in serum isolated from blood collected at 0, 2, 4, 6, 8, and 24 h after LPS administration of the mice (with or without drug treatment). The results showed that there was a lower production of TNFα, IL-6, and IL-1β in the serum of LPS-challenged mice that had been pre-treated with pinocembrin. In addition, pre-treatment with pinocembrin improved host survival against the LPS-induced lethal endotoxemia. These results suggest that this new flavonoid could potentially be a novel candidate for preventing development/mitigation progression of septic shock.

• Authors: Lanan Wassy Soromou, Lanxiang Jiang, Miaomiao Wei, Na Chen, Meixia Huo, Xiao Chu, Weiting Zhong, Qianchao Wu, Abdourahmane Baldé, Xuming Deng, Haihua Feng
• Journal: Journal of immunotoxicology (J Immunotoxicol) 2014 Jan-Mar Vol. 11 Issue 1 Pg. 56-61 ISSN: 1547-6901 [Electronic] England
• PMID: 23697399 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Cytokines
• Flavanones
• Inflammation Mediators
• Lipopolysaccharides
• pinocembrin

Topics

• Animals
• Anti-Inflammatory Agents (administration & dosage)
• Cytokines (blood)
• Disease Models, Animal
• Flavanones (administration & dosage)
• Gene Expression Regulation
• Humans
• Inflammation Mediators (blood)
• Lipopolysaccharides (immunology)
• Male
• Medicine, Chinese Traditional
• Mice
• Mice, Inbred BALB C
• Phytotherapy (trends)
• Shock, Septic
• Turnera (immunology)