Radioimmune localization of occult carcinoma.

Abstract

Patients with a rising serum carcinoembryonic antigen level and no clinical or roentgenographic evidence of recurrent or metastatic cancer present a treatment dilemma. Eleven such patients, 10 with a previously treated colorectal carcinoma and 1 with a previously treated breast carcinoma, received an injection of the anticarcinoembryonic antigen monoclonal antibody ZCE-025 labeled with the radioisotope indium 111. Nuclear scintigraphy was performed on days 3 and 5 through 7 to detect potential sites of tumor recurrence. The monoclonal antibody scan accurately predicted the presence or absence of occult malignancy in 7 (64%) patients. Second-look laparotomy confirmed the monoclonal antibody scan results in the patients with colorectal cancer, and magnetic resonance imaging confirmed metastatic breast cancer. This study demonstrates that In-ZCE-025 can localize occult carcinoma and may assist the surgeon in facilitating the operative exploration. In-ZCE-025 assisted in the initiation of adjuvant therapy for the patient with breast cancer.

• Authors: R B Duda, A M Zimmer, S T Rosen, K A Gilyon, D Webber, S Spies, W Spies, B Merchant
• Journal: Archives of surgery (Chicago, Ill. : 1960) (Arch Surg) Vol. 125 Issue 7 Pg. 866-70 (Jul 1990) ISSN: 0004-0010 [Print] United States
• PMID: 2369311 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• Carcinoembryonic Antigen
• Citrates
• Indium Radioisotopes
• Citric Acid

Topics

• Antibodies, Monoclonal
• Breast Neoplasms (diagnostic imaging)
• Carcinoembryonic Antigen (analysis)
• Citrates
• Citric Acid
• Colorectal Neoplasms (diagnostic imaging, surgery)
• Humans
• Indium Radioisotopes
• Injections, Intravenous
• Liver Neoplasms (diagnostic imaging, secondary)
• Neoplasm Recurrence, Local (diagnostic imaging)
• Neoplasms, Unknown Primary (blood, diagnostic imaging)
• Radiography
• Radionuclide Imaging
• Reoperation