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Anti-inflammatory activity and composition of Senecio salignus Kunth.

Abstract
We investigated the anti-inflammatory activity of Senecio salignus. This medicinal plant is often used in Mexico for the treatment of fever and rheumatism. Chloroform and methanol extracts of the plant were tested on 12-O-tetradecanoylphorbol-13-acetate- (TPA-) induced edema in mice ears. The methanol extract of the plant inhibited edema by 36 ± 4.4% compared with the control, while the chloroform extract exhibited an even greater level of inhibition (64.1%). The chloroform extract was then fractionated, and the composition of the active fraction was determined by GC-MS. The anti-inflammatory activity of this fraction was then tested on TPA-induced ear edema in mice, and we found that the active fraction could inhibit edema by 46.9%. The anti-inflammatory effect of the fraction was also tested on carrageenan-induced paw edema in rats at doses of 100 mg/kg; a 58.9 ± 2.8% reduction of the edema was observed 4 h after administration of carrageenan, and the effect was maintained for 5 h.
AuthorsCuauhtemoc Pérez González, Roberto Serrano Vega, Marco González-Chávez, Miguel Angel Zavala Sánchez, Salud Pérez Gutiérrez
JournalBioMed research international (Biomed Res Int) Vol. 2013 Pg. 814693 ( 2013) ISSN: 2314-6141 [Electronic] United States
PMID23691512 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Plant Extracts
  • Carrageenan
Topics
  • Animals
  • Anti-Inflammatory Agents (pharmacology, therapeutic use)
  • Carrageenan
  • Edema (drug therapy)
  • Male
  • Mice
  • Plant Extracts (pharmacology, therapeutic use)
  • Rats
  • Rats, Wistar
  • Senecio (chemistry)

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