Serum amyloid A-positive hepatocellular neoplasms in the resected livers from 3 patients with alcoholic cirrhosis.

Abstract

Twelve hepatocellular nodules were characterized in the resected livers from 3 patients (2 men and a woman) with alcoholic cirrhosis. Imaging techniques suggested that the nodules were hypervascular and may be hepatocellular carcinoma. Five nodules (4-31 mm in diameter) were serum amyloid A-positive hepatocellular neoplasm, which shares features with inflammatory hepatocellular adenoma. The remaining 7 nodules (5-8 mm) were focal nodular hyperplasia-like nodules showing focal or no immunostaining for serum amyloid A. The serum amyloid A-positive hepatocellular neoplasms showed increased cellular density, inflammatory infiltrate, sinusoidal dilatation, and ductular reaction to various degrees. These histologic features tended to be less extensive in focal nodular hyperplasia-like nodules. Three of 4 serum amyloid A-positive hepatocellular neoplasms showed slight hypointensity in the hepatobiliary phase on the magnetic resonance (MR) imaging with gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) enhancement. In contrast, 3 focal nodular hyperplasia-like nodules showed iso-intensity in the hepatobiliary phase. This study further confirms characteristics of serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis that share features with inflammatory hepatocellular adenomas. Serum amyloid A-positive hepatocellular neoplasms sometimes co-exist with focal nodular hyperplasia-like nodules and may show different findings on Gd-EOB-enhanced MR imaging.

• Authors: Motoko Sasaki, Fukuo Kondo, Yoshiyuki Sawai, Yasuharu Imai, Susumu Kadowaki, Keiji Sano, Toshio Fukusato, Osamu Matsui, Yasuni Nakanuma
• Journal: Histology and histopathology (Histol Histopathol) Vol. 28 Issue 11 Pg. 1499-505 (11 2013) ISSN: 1699-5848 [Electronic] Spain
• PMID: 23690168 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Serum Amyloid A Protein

Topics

• Adult
• Carcinoma, Hepatocellular (complications, metabolism, pathology)
• Female
• Humans
• Immunohistochemistry
• Liver Cirrhosis, Alcoholic (complications, pathology)
• Liver Neoplasms (complications, metabolism, pathology)
• Male
• Middle Aged
• Serum Amyloid A Protein (metabolism)