HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients.

AbstractBACKGROUND:
Evidence suggests that cytoglobin (Cygb) may function as a tumor suppressor gene.
METHODS:
We immunohistochemically evaluated the expression of Cygb, phosphatidylinositol-3 kinase (PI-3K), phosphorylated (p)-Akt, Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and vascular endothelial growth factor (VEGF) in 88 patients with 41 high-grade gliomas and 47 low-grade gliomas. Intratumoral microvessel density (IMD) was also determined and associated with clinicopathological factors.
RESULTS:
Low expression of Cygb was significantly associated with the higher histological grading and tumor recurrence. A significant negative correlation emerged between Cygb expression and PI3K, p-Akt, IL-6, TNFα or VEGF expression. Cygb expression was negatively correlated with IMD. There was a positive correlation between PI3K, p-Akt, IL-6, TNFα and VEGF expression with IMD.High histologic grade, tumor recurrence, decreased Cygb expression, increased PI3K expression, increased p-Akt expression and increased VEGF expression correlated with patients' overall survival in univariate analysis. However, only histological grading and Cygb expression exhibited a relationship with survival of patients as independent prognostic factors of glioma by multivariate analysis.
CONCLUSIONS:
Cygb loss may contribute to tumor recurrence and a worse prognosis in gliomas. Cygb may serve as an independent predictive factor for prognosis of glioma patients.
AuthorsHong-Wu Xu, Yue-Jun Huang, Ze-Yu Xie, Lan Lin, Yan-Chun Guo, Ze-Rui Zhuang, Xin-Peng Lin, Wen Zhou, Mu Li, Hai-Hua Huang, Xiao-Long Wei, Kwan Man, Guo-Jun Zhang
JournalBMC cancer (BMC Cancer) Vol. 13 Pg. 247 (May 20 2013) ISSN: 1471-2407 [Electronic] England
PMID23688241 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CYGB protein, human
  • Cytoglobin
  • Interleukin-1
  • Tumor Necrosis Factor-alpha
  • Vascular Endothelial Growth Factor A
  • Globins
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-akt
Topics
  • Adolescent
  • Adult
  • Aged
  • Analysis of Variance
  • Brain Neoplasms (metabolism, pathology)
  • Cytoglobin
  • Female
  • Glioma (metabolism, pathology)
  • Globins (metabolism)
  • Humans
  • Interleukin-1 (metabolism)
  • Kaplan-Meier Estimate
  • Male
  • Microvessels (pathology)
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Grading
  • Neoplasm Recurrence, Local (metabolism)
  • Phosphatidylinositol 3-Kinases (metabolism)
  • Phosphorylation
  • Proportional Hazards Models
  • Proto-Oncogene Proteins c-akt (metabolism)
  • Retrospective Studies
  • Signal Transduction
  • Tumor Necrosis Factor-alpha (metabolism)
  • Vascular Endothelial Growth Factor A (metabolism)
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: