Abstract | BACKGROUND: Evidence suggests that cytoglobin (Cygb) may function as a tumor suppressor gene. METHODS: RESULTS: Low expression of Cygb was significantly associated with the higher histological grading and tumor recurrence. A significant negative correlation emerged between Cygb expression and PI3K, p-Akt, IL-6, TNFα or VEGF expression. Cygb expression was negatively correlated with IMD. There was a positive correlation between PI3K, p-Akt, IL-6, TNFα and VEGF expression with IMD.High histologic grade, tumor recurrence, decreased Cygb expression, increased PI3K expression, increased p-Akt expression and increased VEGF expression correlated with patients' overall survival in univariate analysis. However, only histological grading and Cygb expression exhibited a relationship with survival of patients as independent prognostic factors of glioma by multivariate analysis. CONCLUSIONS: Cygb loss may contribute to tumor recurrence and a worse prognosis in gliomas. Cygb may serve as an independent predictive factor for prognosis of glioma patients.
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Authors | Hong-Wu Xu, Yue-Jun Huang, Ze-Yu Xie, Lan Lin, Yan-Chun Guo, Ze-Rui Zhuang, Xin-Peng Lin, Wen Zhou, Mu Li, Hai-Hua Huang, Xiao-Long Wei, Kwan Man, Guo-Jun Zhang |
Journal | BMC cancer
(BMC Cancer)
Vol. 13
Pg. 247
(May 20 2013)
ISSN: 1471-2407 [Electronic] England |
PMID | 23688241
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CYGB protein, human
- Cytoglobin
- Interleukin-1
- Tumor Necrosis Factor-alpha
- Vascular Endothelial Growth Factor A
- Globins
- Phosphatidylinositol 3-Kinases
- Proto-Oncogene Proteins c-akt
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Topics |
- Adolescent
- Adult
- Aged
- Analysis of Variance
- Brain Neoplasms
(metabolism, pathology)
- Cytoglobin
- Female
- Glioma
(metabolism, pathology)
- Globins
(metabolism)
- Humans
- Interleukin-1
(metabolism)
- Kaplan-Meier Estimate
- Male
- Microvessels
(pathology)
- Middle Aged
- Multivariate Analysis
- Neoplasm Grading
- Neoplasm Recurrence, Local
(metabolism)
- Phosphatidylinositol 3-Kinases
(metabolism)
- Phosphorylation
- Proportional Hazards Models
- Proto-Oncogene Proteins c-akt
(metabolism)
- Retrospective Studies
- Signal Transduction
- Tumor Necrosis Factor-alpha
(metabolism)
- Vascular Endothelial Growth Factor A
(metabolism)
- Young Adult
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