Abstract | INTRODUCTION: For appropriately staged non-small cell lung cancer (NSCLC) surgical resection can dramatically improve survival, but some may not be offered this treatment because of concerns about perioperative mortality. METHODS: We used data from the National Lung Cancer Audit ( NLCA) to determine the proportions of English patients who died within 30 and 90 days after surgery for NSCLC. We quantified the predictors of early postoperative death and using these results devised a score to predict risk of death within 90 days of surgery. RESULTS: We analysed data on 10 991 patients operated on between 2004 and 2010. Three per cent (334) of patients died within 30 days of their procedure and 5.9% (647) within 90 days. Age was strongly associated with early postoperative death (adjusted OR within 90 days for 80-84 years vs 70-74 years: 1.46, 95% CI 1.07 to 1.98); significant associations were also observed with performance status (PS) (adjusted OR within 90 days for PS 2 vs PS 0: 2.40, 95% CI 1.68 to 3.41), as well as lung function, stage and procedure type. CONCLUSIONS: Our results show that age is the most important predictor of death within both of these early postoperative periods. We used the data in the NLCA to develop a predictive score, based on an English population and specific to lung cancer surgery, which estimates risk of death within 90 days; this score should be tested in future cohorts.
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Authors | Helen A Powell, Laila J Tata, David R Baldwin, Rosamund A Stanley, Aamir Khakwani, Richard B Hubbard |
Journal | Thorax
(Thorax)
Vol. 68
Issue 9
Pg. 826-34
(Sep 2013)
ISSN: 1468-3296 [Electronic] England |
PMID | 23687050
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Age Factors
- Aged
- Aged, 80 and over
- Carcinoma, Non-Small-Cell Lung
(mortality, pathology, surgery)
- Confidence Intervals
- England
(epidemiology)
- Female
- Forecasting
- Humans
- Lung
(physiopathology)
- Lung Neoplasms
(mortality, pathology, surgery)
- Male
- Middle Aged
- Neoplasm Staging
- Odds Ratio
- Pneumonectomy
(mortality)
- Respiratory Function Tests
- Risk Factors
- Sex Factors
- Time Factors
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