Successful treatment of systemic blastomycosis with high-dose ketoconazole in a renal transplant recipient.

Abstract

A case of disseminated blastomycosis in a male renal transplant recipient is presented. Discontinuation of immunosuppressive therapy and treatment with high-dose ketoconazole was successful in treating the patient's cutaneous and pulmonary disease initially. Ketoconazole was discontinued after 12 months of chronic therapy, but 2 weeks after discontinuation, blastomycosis recurred. High-dose ketoconazole was again effective; the patient remains asymptomatic presently on chronic suppressive therapy with ketoconazole.

• Authors: J H Hii, L Legault, G DeVeber, S I Vas
• Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation (Am J Kidney Dis) Vol. 15 Issue 6 Pg. 595-7 (Jun 1990) ISSN: 0272-6386 [Print] United States
• PMID: 2368699 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ketoconazole

Topics

• Aged
• Blastomycosis (drug therapy)
• Chronic Disease
• Dermatomycoses (drug therapy)
• Humans
• Ketoconazole (administration & dosage, therapeutic use)
• Kidney Transplantation
• Lung Diseases, Fungal (drug therapy)
• Male
• Postoperative Complications (drug therapy)