The effect of leptin, caffeine/ephedrine, and their combination upon visceral fat mass and weight loss.

Abstract

OBJECTIVE:

To evaluate the effects of combination caffeine/ephedrine and leptin A-200 on visceral fat mass and weight loss over 24 weeks.

DESIGN AND METHODS:

In this randomized, double-blind, parallel-arm trial, 90 obese subjects received one of the three treatments for 24 weeks: 200 mg caffeine/20 mg ephedrine t.i.d. (CE), leptin A-200 (recombinant methionyl human Fc-leptin, 20 mg q.d.) (L), or combination leptin A-200 and caffeine/ephedrine (LCE). Outcomes included change in weight, visceral fat mass by computed tomography, lean mass and fat mass by dual energy X-ray absorptiometry.

RESULTS:

Groups treated with CE and LCE lost significant amounts of weight (-5.9 ± 1.2% and -6.5 ± 1.1%, P < 0.05) and whole body fat mass (-9.6 ± 2.4% and -12.4 ± 2.3%, P < 0.05) compared to leptin only group. Only treatment with LCE significantly reduced visceral fat mass (-11.0 ± 3.3%, P < 0.05). There were no differences in lean mass between treatment groups.

CONCLUSIONS:

Our study provides evidence that CE is a modestly effective weight loss agent and produces significant reductions in fat mass. Leptin A-200 was not effective in producing weight loss and did not have any significant additive or synergistic actions when combined with CE.

• Authors: Ann G Liu, Steven R Smith, Ken Fujioka, Frank L Greenway
• Journal: Obesity (Silver Spring, Md.) (Obesity (Silver Spring)) Vol. 21 Issue 10 Pg. 1991-6 (Oct 2013) ISSN: 1930-739X [Electronic] United States
• PMID: 23686786 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 The Obesity Society.

Chemical References

• Drug Combinations
• Leptin
• caffeine, ephedrine drug combination
• recombinant methionyl human leptin
• Caffeine
• Ephedrine

Topics

• Absorptiometry, Photon
• Adolescent
• Adult
• Body Composition
• Body Weight
• Caffeine (pharmacology)
• Double-Blind Method
• Drug Combinations
• Drug Therapy, Combination
• Ephedrine (pharmacology)
• Female
• Humans
• Intra-Abdominal Fat (drug effects, metabolism)
• Leptin (analogs & derivatives, pharmacology)
• Male
• Middle Aged
• Obesity (drug therapy)
• Weight Loss (drug effects)
• Young Adult