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The in vivo immunomodulatory and synergistic anti-tumor activity of thymosin α1-thymopentin fusion peptide and its binding to TLR2.

Abstract
In the present study, the immunomodulatory and synergistic anti-tumor activity of thymosin α1-thymopentin fusion peptide (Tα1-TP5) was investigated in vivo. In addition, the potential receptor of Tα1-TP5 was investigated by surface plasmon resonance (SPR) binding studies. It was found that Tα1-TP5 (305 μg/kg) alleviated immunosuppression induced by hydrocortisone (HC). Tα1-TP5 (305 μg/kg) combined with cyclophosphamide (CY) had a better tumor growth inhibitory effect than CY alone. Furthermore, Tα1-TP5 had a higher affinity (KD=6.84 μmol/L) to toll-like receptor 2 (TLR2) than Tα1 (K(D)=35.4 μmol/L), but its affinity was not significantly different from that of TP5. The results of our present work indicate that Tα1-TP5 can possibly be developed as a new immunomodulatory agent.
AuthorsJuan Li, Yanna Cheng, Xinke Zhang, Lei Zheng, Zhen Han, Pingli Li, Yuliang Xiao, Qian Zhang, Fengshan Wang
JournalCancer letters (Cancer Lett) Vol. 337 Issue 2 Pg. 237-47 (Sep 1 2013) ISSN: 1872-7980 [Electronic] Ireland
PMID23684552 (Publication Type: Journal Article)
CopyrightCopyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Antigens, CD86
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Cd86 protein, mouse
  • Histocompatibility Antigens Class I
  • Immunologic Factors
  • Immunosuppressive Agents
  • Tlr2 protein, mouse
  • Toll-Like Receptor 2
  • thymalfasin
  • Thymosin
  • Interferon-gamma
  • Cyclophosphamide
  • Thymopentin
  • Hydrocortisone
Topics
  • Animals
  • Antigens, CD86 (metabolism)
  • Antineoplastic Agents (immunology, metabolism, pharmacology)
  • Antineoplastic Agents, Alkylating (pharmacology)
  • Antineoplastic Combined Chemotherapy Protocols (pharmacology)
  • Atrophy
  • Cyclophosphamide (pharmacology)
  • Drug Synergism
  • Histocompatibility Antigens Class I (metabolism)
  • Hydrocortisone (pharmacology)
  • Immunologic Factors (metabolism, pharmacology)
  • Immunosuppressive Agents (pharmacology)
  • Interferon-gamma (blood)
  • Male
  • Melanoma, Experimental (drug therapy, immunology, pathology)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Protein Binding
  • Skin Neoplasms (drug therapy, immunology, pathology)
  • Surface Plasmon Resonance
  • Thymocytes (drug effects, immunology, pathology)
  • Thymopentin (immunology, metabolism, pharmacology)
  • Thymosin (analogs & derivatives, immunology, metabolism, pharmacology)
  • Thymus Gland (drug effects, immunology, pathology)
  • Time Factors
  • Toll-Like Receptor 2 (metabolism)
  • Tumor Burden (drug effects)

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