Abstract | OBJECTIVE: DESIGN: Thirty-five overweight or obese subjects with type 2 diabetes were randomized to receive intensive lifestyle modification including supervised exercise sessions or usual care for 12 weeks. Anthropometric and clinical data were collected before the intervention and after 12 weeks. RESULTS: Lifestyle intervention induced a significant decrease in HbA1c (-1·0 ± 0·5 vs 0·1 ± 0·6%, P < 0·001), BMI, total body fat content, serum lipocalin-2 and chemerin levels (-8·1 ± 21·6 vs + 8·2 ± 15·9 ng/ml, P = 0·021) and a significant increase in VO2 max after 12 weeks compared to the usual care group. Baseline chemerin levels were positively correlated with the homoeostasis model of assessment of insulin resistance (HOMA-IR), fasting insulin and the high-sensitivity C-reactive protein ( hsCRP) and negatively correlated with insulin sensitivity index (ISI). Changes in the chemerin concentration during 12 weeks were independently negatively correlated with changes in ISI and positively correlated with changes in fasting plasma glucose, total cholesterol and lipocalin-2 levels. CONCLUSIONS: A 12-week intensive lifestyle intervention significantly decreased serum chemerin level compared to usual care. Decrease in serum chemerin level was associated with improved insulin sensitivity, and this may be involved in the beneficial effects of lifestyle intervention in overweight and obese type 2 diabetic patients.
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Authors | So Hun Kim, Seung Hwan Lee, Ki Yong Ahn, Dong Hoon Lee, Young Ju Suh, Soon Gu Cho, Yun Jin Choi, Dae Hyung Lee, Seung Youn Lee, Seong Bin Hong, Yong Seong Kim, Justin Y Jeon, Moonsuk Nam |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 80
Issue 6
Pg. 825-33
(Jun 2014)
ISSN: 1365-2265 [Electronic] England |
PMID | 23682797
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 John Wiley & Sons Ltd. |
Chemical References |
- Acute-Phase Proteins
- Blood Glucose
- CMKLR1 protein, human
- Insulin
- LCN2 protein, human
- Lipocalin-2
- Lipocalins
- Proto-Oncogene Proteins
- Receptors, Chemokine
- C-Reactive Protein
- Cholesterol
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Topics |
- Acute-Phase Proteins
- Adult
- Anthropometry
- Blood Glucose
(analysis)
- Body Mass Index
- C-Reactive Protein
(metabolism)
- Cholesterol
(blood)
- Diabetes Mellitus, Type 2
(blood)
- Diet
- Female
- Homeostasis
- Humans
- Insulin
(blood)
- Insulin Resistance
- Life Style
- Lipocalin-2
- Lipocalins
(blood)
- Male
- Metabolic Syndrome
(blood)
- Middle Aged
- Obesity
(blood)
- Overweight
(blood)
- Proto-Oncogene Proteins
(blood)
- Receptors, Chemokine
(blood)
- Risk Factors
- Treatment Outcome
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